Results 221 to 230 of about 12,379,215 (250)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Adaptive Neural Control for Constrained Biomimetic Rehabilitation Robots Using a Novel High-Order Integral Barrier Function. [PDF]

Biomimetics (Basel)
Zhang T, Zhang J, Yan P.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Topologically-based parameter inference for agent-based model selection from spatiotemporal cellular data. [PDF]

PLoS Comput Biol
Wenzel AR, Haughey PM, Nguyen KC, Nardini JT, Haugh JM, Flores KB.   +5 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Method Comparison of PT, INR, and aPTT Results Obtained Using Two Coagulation Analyzers in Routine Laboratory Practice. [PDF]

Diagnostics (Basel)
Özbek Kurtul B, Dündar B, Gündoğan Gİ, Sevinc SK, Elgün T, Yurttaş AG.   +5 more
europepmc   +1 more source

Global Existence and Nonlinear Stability of Finite-Energy Solutions of the Compressible Euler-Riesz Equations with Large Initial Data of Spherical Symmetry. [PDF]

Commun Math Phys
Carrillo JA, Charles SR, Chen GG, Yuan D.   +3 more
europepmc   +1 more source

An efficient multiplier-based FPGA CNN accelerator for Parkinson's disease detection using hand-drawn circle images. [PDF]

Front Artif Intell
A V, Sathasivam S, Ramachandran P.
europepmc   +1 more source

A highly accurate Hermite polynomial-based least-squares approach for solving fractional Volterra-Fredholm integro-differential equations. [PDF]

PLoS One
Hamood MM, Sharif AA, Ghadle KP.
europepmc   +1 more source