Results 61 to 70 of about 4,524 (286)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A design methodology for approximate multipliers in convolutional neural networks: A case of MNIST

, 2023
In this paper, we present a case study on approximate multipliers for MNIST Convolutional Neural Network (CNN). We apply approximate multipliers with different bit-width to the convolution layer in MNIST CNN, evaluate the accuracy of MNIST ...
Kenta Shirane, Hiroyuki Tomiyama, Takahiro Yamamoto   +2 more
core   +1 more source

ILP-Based and Heuristic Scheduling Techniques for Variable-Cycle Approximate Functional Units in High-Level Synthesis

Computers, 2022
Approximate computing is a promising approach to the design of area–power-performance-efficient circuits for computation error-tolerant applications such as image processing and machine learning.
Koyu Ohata, Hiroki Nishikawa, Xiangbo Kong, Hiroyuki Tomiyama   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Low power approximate multipliers for energy efficient data processing

, 2018
Computation accuracy can be adequately tuned on the specific application requirements in order to reduce power consumption. To give some examples, image processing and audio/speech recognition e.g., multimedia applications may provide more accurate ...
OSTA, MARIO, Chible H., Seminara L., Valle M., Ibrahim A.   +4 more
core   +1 more source

Design and evaluation of clock-gating-based approximate multiplier for error-tolerant applications

Memories - Materials, Devices, Circuits and Systems
The multipliers are essential components in real-time applications. Although approximation arithmetic affects the output accuracy in multipliers, it offers a realistic avenue for constructing power-, area--, and speed-efficient digital circuits.
Venkata Sudhakar Chowdam, Suresh Babu Potladurty, Prasad Reddy karipireddy   +2 more
doaj   +1 more source

A High Speed Approximate Multiplier Design [PDF]

Jisuanji gongcheng, 2019
Approximate compute,as a new calculation method that effectively balances accuracy and performance,has been widely used in applications such as image processing,data mining,and multimedia technology that can tolerate a small number of computational ...
WU Dexiang, BAN Tian
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source