Results 41 to 50 of about 3,564 (253)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Design and evaluation of clock-gating-based approximate multiplier for error-tolerant applications

Memories - Materials, Devices, Circuits and Systems
The multipliers are essential components in real-time applications. Although approximation arithmetic affects the output accuracy in multipliers, it offers a realistic avenue for constructing power-, area--, and speed-efficient digital circuits.
Venkata Sudhakar Chowdam, Suresh Babu Potladurty, Prasad Reddy karipireddy   +2 more
doaj   +1 more source

An Approximate GEMM Unit for Energy-Efficient Object Detection

Sensors, 2021
Edge computing brings artificial intelligence algorithms and graphics processing units closer to data sources, making autonomy and energy-efficient processing vital for their design.
Ratko Pilipović, Vladimir Risojević, Janko Božič, Patricio Bulić, Uroš Lotrič   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Efficient Approximate Recursive Multipliers (EARM) for Area and Power Optimized Image Processing Applications

IEEE Access
This paper proposes a novel approximate multiplier designed to improve efficiency in digital systems by exploiting controlled approximation while minimizing hardware requirements.
Kankanala Srinivas, Gundugonti Kishore Kumar   +1 more
doaj   +1 more source

ILP-Based and Heuristic Scheduling Techniques for Variable-Cycle Approximate Functional Units in High-Level Synthesis

Computers, 2022
Approximate computing is a promising approach to the design of area–power-performance-efficient circuits for computation error-tolerant applications such as image processing and machine learning.
Koyu Ohata, Hiroki Nishikawa, Xiangbo Kong, Hiroyuki Tomiyama   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A High Speed Approximate Multiplier Design [PDF]

Jisuanji gongcheng, 2019
Approximate compute,as a new calculation method that effectively balances accuracy and performance,has been widely used in applications such as image processing,data mining,and multimedia technology that can tolerate a small number of computational ...
WU Dexiang, BAN Tian
doaj   +1 more source