Results 191 to 200 of about 395,042 (229)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Measuring the Approximate Number System [PDF]

Quarterly Journal of Experimental Psychology, 2011
Recent theories in numerical cognition propose the existence of an approximate number system (ANS) that supports the representation and processing of quantity information without symbols. It has been claimed that this system is present in infants, children, and adults, that it supports learning of symbolic mathematics, and that correctly harnessing the
Matthew Inglis, Nina Attridge, Camilla Gilmore   +2 more
exaly   +3 more sources

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The representations of the approximate number system

Philosophical Psychology, 2021
The Approximate Number System (ANS) is a system that allows us to distinguish between collections based on the number of items, though only if the ratio between numbers is high enough.
Stefan Buijsman
exaly   +2 more sources

Contents of the approximate number system

Behavioral and Brain Sciences, 2021
Abstract Clarke and Beck argue that the approximate number system (ANS) represents rational numbers, like 1/3 or 3.5. I think this claim is not supported by the evidence. Rather, I argue, ANS should be interpreted as representing natural numbers and ratios among them; and we should view the contents of these representations are genuinely approximate.
openaire   +2 more sources

The Approximate Number System is not Predictive for Symbolic Number Processing in Kindergarteners

Quarterly Journal of Experimental Psychology, 2014
The relation between the approximate number system (ANS) and symbolic number processing skills remains unclear. Some theories assume that children acquire the numerical meaning of symbols by mapping them onto the preexisting ANS. Others suggest that in addition to the ANS, children also develop a separate, exact representational system for symbolic ...
Delphine Sasanguie, Bert Reynvoet
exaly   +3 more sources

Children’s mappings between number words and the approximate number system

Cognition, 2015
Humans can represent number either exactly--using their knowledge of exact numbers as supported by language, or approximately--using their approximate number system (ANS). Adults can map between these two systems--they can both translate from an approximate sense of the number of items in a brief visual display to a discrete number word estimate (i.e.,
Darko Odić, Justin Halberda, Mathieu Le Corre   +2 more
exaly   +3 more sources

Characteristic numbers and approximation operators in generalized rough approximation system

International Journal of Approximate Reasoning, 2021
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Bidirectional Mapping Between the Symbolic Number System and the Approximate Number System

Experimental Psychology, 2021
Abstract. Previous studies have discussed the symmetry of bidirectional mapping between approximate number system (ANS) and symbolic number system (SNS). However, these studies neglected the essential significance of bidirectional mapping in the development of numerical cognition.
Lijuan Wang, Xiao Liang, Yueyang Yin, Jingmei Kang   +3 more
openaire   +1 more source

Non-symbolic and symbolic number and the approximate number system

Behavioral and Brain Sciences, 2021
Abstract The distinction between non-symbolic and symbolic number is poorly addressed by the authors despite being relevant in numerical cognition, and even more important in light of the proposal that the approximate number system (ANS) represents rational numbers.
openaire   +2 more sources