Results 201 to 210 of about 291,463 (261)

On the Structural Properties of Discrete-Time and Sampled-Data Hamiltonian Dynamics. [PDF]

Entropy (Basel)
Monaco S, Normand-Cyrot D.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Benchmarking Quantum Solvers in Noisy Digital Simulations for Financial Portfolio Optimization. [PDF]

Entropy (Basel)
Shen R, Hao Z, Lee CH.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A Comprehensive Instrumental Analysis Framework for Assessing the Dissolvability and Taste Properties of Plant Extract Instant Granules. [PDF]

Foods
Ma X, Lin Z, Wang Y, Jiang H, Xie J, Gu Q, Hu Y, Luo G, Xu B.   +8 more
europepmc   +1 more source

Analytical solutions of some time-fractional versions of the coupled KdV system of equations via two hybrid transform techniques. [PDF]

Sci Rep
Aruna K, Okposo NI, Veeresha P, Raghavendar K.   +3 more
europepmc   +1 more source

Parameter-uniform numerical method for a coupled system of singularly perturbed turning point problems with Robin boundary conditions. [PDF]

Sci Rep
Karanam C, Maroju P.
europepmc   +1 more source

Vibrational circular dichroism enhancement in conformationally flexible transition metal complexes.

Phys Chem Chem Phys
Sapova M, de Boer M, Buma WJ, Visscher L.   +3 more
europepmc   +1 more source