Results 51 to 60 of about 737,146 (331)
Improved Approximation Algorithms for Segment Minimization in Intensity Modulated Radiation Therapy
, 2009 he segment minimization problem consists of finding the smallest set of integer matrices that sum to a given intensity matrix, such that each summand has only one non-zero value, and the non-zeroes in each row are consecutive.
Ahuja +16 more
core +2 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Algorithms for ℓp Low Rank Approximation [PDF]
, 2017 We consider the problem of approximating a given matrix by a low-rank matrix so as to minimize the entry-wise ℓp-approximation error, for any P ≥ 1; the case p = 2 is the classical SVD problem.
Chierichetti, Flavio +5 more
core
, 2016 We propose and compare goal-oriented projection based model order reduction methods for the estimation of vector-valued functionals of the solution of parameter-dependent equations.
Billaud-Friess, Marie +2 more
core +2 more sources
Algorithms For Positive Polynomial Approximation [PDF]
SIAM Journal on Numerical Analysis, 2019 Summary: We propose several algorithms for positive polynomial approximation. The main tool is a novel iterative method to compute nonnegative interpolation polynomials at any order, which is shown to converge under conditions that make it suitable for the numerical approximation of positive functions. Our method is based on the special representations
Charles, Frédérique +2 more
openaire +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
MathematicsThe behavior of a new modification of operators of the Baskakov–Schurer–Stancu variant is discussed in this study. First, we establish certain necessary moment and central moment estimates.
Nadire Fulda Odabaşı +3 more
doaj +1 more source
Scheduling Non-Preemptible Jobs to Minimize Peak Demand
Algorithms, 2017 This paper examines an important problem in smart grid energy scheduling; peaks in power demand are proportionally more expensive to generate and provision for. The issue is exacerbated in local microgrids that do not benefit from the aggregate smoothing
Sean Yaw, Brendan Mumey
doaj +1 more source
Improved Approximation Algorithms for Stochastic Matching
, 2015 In this paper we consider the Stochastic Matching problem, which is motivated by applications in kidney exchange and online dating. We are given an undirected graph in which every edge is assigned a probability of existence and a positive profit, and ...
B.C. Dean +4 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source