Results 71 to 80 of about 545,451 (275)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Spectral Effects of Strong Chi-2 Non-Linearity for Quantum Processing
, 2008 Optical $\chi^{(2)}$ non-linearity can be used for parametric amplification and producing down-converted entangled photon pairs that have broad applications. It is known that weak non-linear media exhibit dispersion and produce a frequency response.
A. B. U’Ren +6 more
core +1 more source
Semiclassical Faddeev approximation for electron loss in fast heavy-ion collisions [PDF]
, 1981 . The ionisation of the projectile in collisions with heavy targets is described by means of the Faddeev expansion. The series is cut off after five terms which means an inclusion of higher-order interactions of the electron with both the target and the ...
Jakubaßa-Amundsen, Doris H.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Phase diagram of the hardcore Bose-Hubbard model on a checkerboard superlattice
, 2010 We obtain the complete phase diagram of the hardcore Bose-Hubbard model in the presence of a period-two superlattice in two and three dimensions. First we acquire the phase boundaries between the superfluid phase and the `trivial' insulating phases of ...
Hen, Itay, Iskin, M., Rigol, Marcos
core +1 more source
MPQA method applied to the plasma dispersion function
AIP AdvancesA new approximation method for the plasma dispersion function Z(ζ) is presented. Multipoint quasi-rational approximation technique is used to find a bridge function that connects the power series and the asymptotic expansion of the function Z(ζ) using ...
E. Morales-Campaña, P. Martin
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A Low-Order Series Approximation of Thin-Bed PP-Wave Reflections
Applied Sciences, 2019 The study of thin-bed seismic phenomena is important in crustal, exploration and engineering seismology. Presently, seismic reflectivity theories based on single-interface assumption are widely used though they are only suitable for thick deposits.
Chun Yang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source