Results 51 to 60 of about 315,257 (270)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Nonlinear Bivariate Bernstein–Chlodowsky Operators of Maximum Product Type

Journal of Mathematics, 2022
The positive nonlinear operators with maximum and product were introduced by Bede. In this study, nonlinear maximum product type of bivariate Bernstein–Chlodowsky operators is defined and the approximation properties are investigated with the help of new
Özge Özalp Güller, Ecem Acar, Sevilay Kırcı Serenbay   +2 more
doaj   +1 more source

Approximation theorems for positive operators on L-spaces

Journal of Approximation Theory, 1990
For \(T\in {\mathcal L}(L^ p(m),L^ r(n))\), where (X,\({\mathcal A},m)\) and (Y,\({\mathcal B},n)\) are \(\sigma\)-finite mesure spaces, let \(M(T)=\{f\in L^ p(m):\| Tf\| =\| T\| \| f\| \}\) and \(J(T)=\{\sup p f: f\in M(T)\}\). A linear bounded operator T is said to be positive (T\(\geq 0)\) if Tf\(\geq 0\) whenever \(f\geq 0\).
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

On the approximation of the principal eigenvalue for a class of nonlinear elliptic operators

, 2016
We present a finite difference method to compute the principal eigenvalue and the corresponding eigenfunction for a large class of second order elliptic operators including notably linear operators in nondivergence form and fully nonlinear operators. The
Birindelli, Isabeau, Camilli, Fabio, Dolcetta, Italo Capuzzo   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Caputo fractional approximation by sublinear operators

Journal of Numerical Analysis and Approximation Theory, 2018
Here we consider the approximation of functions by sublinear positive operators with applications to a big variety of Max-Product operators under Caputo fractional differentiability. Our study is based on our general fractional results about positive
George A. Anastassiou
doaj   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Multivariate Approximation by Overactivated and Spiked Multivariate Convolutions as Positive Linear Operators

Axioms
This study quantitatively approximates the unit operator using three types of multivariate, overactivated, and spiked convolution operators. The core of these operators is a multivariate “cusp” kernel, which acts as a novel, compact-support activation ...
George A. Anastassiou
doaj   +1 more source