Results 71 to 80 of about 317,488 (309)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Complete Approximations by Multivariate Generalized Gauss-Weierstrass Singular Integrals

open access: yesMoroccan Journal of Pure and Applied Analysis, 2021
This research and survey article deals exclusively with the study of the approximation of generalized multivariate Gauss-Weierstrass singular integrals to the identity-unit operator.
Anastassiou George A.
doaj   +1 more source

(p,q)-Generalization of Szasz-Mirakyan Operators

open access: yes, 2015
In this paper, we introduce new modifications of Szasz-Mirakyan operators based on (p,q)-integers. We first give a recurrence relation for the moments of new operators and present explicit formula for the moments and central moments up to order 4.
Acar, Tuncer
core   +1 more source

A NEW APPROACH IN OBTAINING A BETTER ESTIMATION IN APPROXIMATION BY POSITIVE LINEAR OPERATORS

open access: yes, 2009
In this study, without preserving some test functions, we present a new approach in obtaining a better error estimation in the approximation by means of positive linear operators.
M. A. Özarslan, O. Duman
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Caputo fractional approximation by sublinear operators

open access: yesJournal of Numerical Analysis and Approximation Theory, 2018
Here we consider the approximation of functions by sublinear positive operators with applications to a big variety of Max-Product operators under Caputo fractional differentiability. Our study is based on our general fractional results about positive
George A. Anastassiou
doaj   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Haagerup approximation property for arbitrary von Neumann algebras

open access: yes, 2015
We attempt presenting a notion of the Haagerup approximation property for an arbitrary von Neumann algebra by using its standard form. We also prove the expected heredity results for this property.Comment: To appear in Publ. Res. Inst.
Okayasu, Rui, Tomatsu, Reiji
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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