Results 61 to 70 of about 148,619 (245)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Explicit representation of the implicit Colebrook–White equation

Case Studies in Thermal Engineering, 2015
It is shown that the Colebrook–White equation 1/λ=−2lg[2.51/Reλ+ϵ/3.71D] can be solved analytically for the friction factor λ. The solution contains two infinite sums.
P. Rollmann, K. Spindler
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Approximate Zeros and Condition Numbers

Journal of Complexity, 1999
The paper is an addendum to the paper \textit{F. Cucker} and \textit{S. Smale} [Lect. Notes Comput. Sci. 1461, 115-126 (1998; Zbl 0929.65027)]. Here, the author proves the same result for a different condition number.
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Analytical Hierarchy Process based on intuitionistic interval approximation of trapezoidal intuitionistic fuzzy numbers

Data Analytics and Applied Mathematics
The fuzzy Analytical Hierarchy Process (AHP) is a method in fuzzy decision-making, which helps decision makers make the best choice of alternatives when dealing with uncertainty.
Nik Muhammad Farhan Hakim Nik Badrul Alam, Ku Muhammad Naim Ku Khalif, Nor Izzati Jaini   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

An application of decision theory on the approximation of a generalized Apollonius-type quadratic functional equation

Journal of Inequalities and Applications
To make better decisions on approximation, we may need to increase reliable and useful information on different aspects of approximation. To enhance information about the quality and certainty of approximating the solution of an Apollonius-type quadratic
Azam Ahadi, Reza Saadati, Tofigh Allahviranloo, Donal O’Regan   +3 more
doaj   +1 more source

Continuity envelopes of spaces of generalised smoothness: a limiting case; embeddings and approximation numbers

Journal of Function Spaces and Applications, 2005
Continuity envelopes for the spaces of generalised smoothness Bpq(s,Ψ)(ℝn) and Fpq(s,Ψ)(ℝn) are studied in the so-called supercritical s=1+n/p, paralleling recent developments for a corresponding limiting case for local growth envelopes of spaces of such
António M. Caetano, Dorothee D. Haroske
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source