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Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner +2 more
wiley +1 more source

Approximation in Hölder spaces

Advances in Mathematics
We introduce new vanishing subspaces of the homogeneous Hölder space $\dot{C}^{0,ω}(X,Y)$ in the generality of a doubling modulus $ω$ and normed spaces $X$ and $Y.$ For many couples $X,Y,$ we show these vanishing subspaces to completely characterize those Hölder functions that admit approximations, in the Hölder seminorm, by smooth, Lipschitz and ...
Mudarra, Carlos, Oikari, Tuomas
openaire +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source

Connectedness In Ideal Approximation space

Wasit Journal for Pure Sciences
In this paper we study the notion connectedness in approximation spaces and ideal connectedness are introduced, with an explanation of their differences.
Huda Mohsin, Faik Mayah
doaj +1 more source

Global approximation in harmonic spaces [PDF]

Proceedings of the American Mathematical Society, 1994
This paper characterizes, in terms of thinness, compact sets K in a suitable harmonic space Ω
Gardiner, Stephen J. +2 more
openaire +1 more source

Plate Heat Exchanger Optimization Using Different Approximation Assisted Multiobjective Optimization Techniques [PDF]

, 2012
This paper presents a comparison between different multiobjective optimization approaches that can be used to optimize the design of thermal equipment. Plate heat exchanger is taken as case study to apply different optimization techniques.
Aute, Vikrant +3 more
core

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn +2 more
wiley +1 more source

Displacement Field Approximations for Force-Based Elements in Large Displacement Analyses

Journal of Applied Mathematics, 2012
This paper investigates different approximation techniques for planar beam column elements in force-based methods. The three fields, introduced in this review, are: curvature-based displacement interpolation (CBDI) used in matrix-based flexibility ...
M. Vahidi, V. Jafari, M. H. Abyaneh, SH. Vahdani +3 more
doaj +1 more source

Approximating equivariant mapping spaces [PDF]

Pacific Journal of Mathematics, 1990
Let $G$ be a finite group and let $V$ be a finite-dimensional unitary representation of $G$ with unit sphere $SV$. Let ${\mathcal U}(SV,SV)$ be the $G$-space of unbased maps $SV\to SV$, where $G$ acts by conjugation. Let also $S^ V$ denote the one-point compactification of $V$ and let $\Omega^ VS^ V$ denote the $G$-space of ...
Costenoble, S. R., Waner, S., Wells, G. S. +2 more
openaire +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source

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