Results 61 to 70 of about 48,526 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Asteroid resource map for near-Earth space

, 2011
Most future concepts for the exploration and exploitation of space require a large initial mass in low Earth orbit. Delivering this required mass from the Earth’s surface increases cost due to the large energy input necessary to move mass out of the ...
Sanchez Cuartielles, Joan-Pau, Sanchez, J. P., McInnes, Colin, McInnes, C., J. P. Sanchez, C. McInnes   +5 more
core   +1 more source

Implicit difference approximation for the two-dimensional space-time fractional diffusion equation [PDF]

, 2006
In this paper, we consider a two-dimensional fractional space-time diffusion equation (2DFSTDE) on a finite domain. We examine an implicit difference approximation to solve the 2DFSTDE. Stability and convergence of the method are discussed.
Liu, Fawang, Zhuang, Pinghui, Liu F., Zhuang P.   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Best Approximation Of Bounded Functions By Continuous Functions

, 2015
[No abstract available]412135148Amir, Chebyshev centers and uniform convexity (1978) Pacific Journal of Mathematics, 77, pp. 1-6Amir, Deutsch, Approximation by certain subspaces in the Banach space of continuous vector-valued functions (1979) J.
Roversi M.S.M., ROVERSI, MSM
core   +1 more source

New Generalization of -Best Simultaneous Approximation in Topological Vector Spaces

Abstract and Applied Analysis, 2013
Let be a nonempty subset of a Hausdorff topological vector space , and let be a real-valued continuous function on . If for each , there exists such that , then is called -simultaneously proximal and is called -best simultaneous approximation for ...
Mahmoud Rawashdeh, Sarah Khalil
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Approximation by Jakimovski–Leviatan-beta operators in weighted space

Advances in Difference Equations, 2020
The main purpose of this article is to introduce a more generalized version of Jakimovski–Leviatan-beta operators through the Appell polynomials. We present some uniform convergence results of these operators via Korovkin’s theorem and obtain the rate of
M. Nasiruzzaman, M. Mursaleen
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Approximate property of a functional equation with a general involution

Demonstratio Mathematica, 2018
In this paper, we prove the Hyers-Ulam stability of the functional equation f(x + y, z + w) + f(x + σ(y),z + τ(w)) = 2f(x, z) + 2f(y, w), where σ, τ are involutions.
Park Won-Gil, Bae Jae-Hyeong
doaj   +1 more source