Results 41 to 50 of about 76,024 (266)

Solving the General Fuzzy Random Bilevel Programming Problem Through $Me$ Measure-Based Approach

open access: yesIEEE Access, 2018
This paper addresses the general fuzzy random bilevel programming problem in which not only both objective functions, but also the constraints contain fuzzy random variable coefficients.
Aihong Ren
doaj   +1 more source

Approximate Deadline-Scheduling with Precedence Constraints [PDF]

open access: yes, 2015
We consider the classic problem of scheduling a set of n jobs non-preemptively on a single machine. Each job j has non-negative processing time, weight, and deadline, and a feasible schedule needs to be consistent with chain-like precedence constraints. The goal is to compute a feasible schedule that minimizes the sum of penalties of late jobs. Lenstra
Efsandiari, Hossein   +5 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

METHOD OF FIRST-ORDER APPROXIMATIONS OF INTER FORCE FOR STRUCTURAL TOPOLOGY OPTIMIZATION WITH STRESS CONSTRAINTS

open access: yesJixie qiangdu, 2016
To solve the large computation and low efficiency of stress approximation in structural topology optimization with stress constraints,a method of the first-order approximation of internal force is put forward to express explicitly stress constraints.And ...
PENG XiRong, SUI YunKang
doaj  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Linearized model for optimization of coupled electricity and natural gas systems

open access: yesJournal of Modern Power Systems and Clean Energy, 2017
In this paper a combined optimization of a coupled electricity and gas system is presented. For the electricity network a unit commitment problem with optimization of energy and reserves under a power pool, considering all system operational and unit ...
Mathias SIRVENT   +3 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Multiscale Model Reduction with Local Online Correction for Polymer Flooding Process in Heterogeneous Porous Media

open access: yesMathematics, 2023
In this work, we consider a polymer flooding process in heterogeneous media. A system of equations for pressure, water saturation, and polymer concentration describes a mathematical model.
Maria Vasilyeva, Denis Spiridonov
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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