Results 51 to 60 of about 76,024 (266)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Formulations and Approximations of Branch Flow Model for General Power Networks
Journal of Modern Power Systems and Clean Energy, 2022 The formulations and approximations of the branch flow model for general (radial and mesh) power networks (General-BranchFlow) are given in this paper.
Zhao Yuan
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Researches on the problem of link disjoint paths pair with QoS constraints
Tongxin xuebao, 2006 The problem of link disjoint paths pair with QoS constraints was discussed.Two routing models about link dis-joint optimal paths pair with QoS constraints were constructed.First it proved that the problem of link disjoint paths pair in the undirected ...
ZHANG Pin 1 +3 more
doaj +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Multiplierless approximation of transforms with adder constraint [PDF]
IEEE Signal Processing Letters, 2002 This letter describes an algorithm for systematically finding a multiplierless approximation of transforms by replacing floating-point multipliers with VLSI-friendly binary coefficients of the form k/2/sup n/. Assuming the cost of hardware binary shifters is negligible, the total number of binary adders employed to approximate the transform can be ...
Ying-Jui Chen +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
A cost function approximation method for dynamic vehicle routing with docking and LIFO constraints
Multimodal TransportationIn this paper, we study a dynamic pickup and delivery problem with docking constraints. There is a homogeneous fleet of vehicles to serve pickup-and-delivery requests at given locations.
Markó Horváth +2 more
doaj +1 more source