Results 71 to 80 of about 76,024 (266)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao +5 more
wiley +1 more source
On constrained uniform approximation
International Journal of Mathematics and Mathematical Sciences, 2002 The problem of uniform approximants subject to Hermite interpolatory constraints is considered with an alternate approach. The uniqueness and the convergence aspects of this problem are also discussed. Our approach is based on work of P.
M. A. Bokhari
doaj +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Optimal with Respect to Accuracy Recovery of Some Classes Functions by Fourier Series
Кібернетика та комп'ютерні технологіїIntroduction. Function approximation (approximation or restoration) is widely used in data analysis, model building, and forecasting. The goal of function approximation is to find the function that best approximates the original function.
Olena Kolomys
doaj +1 more source
Approximately Stable Matchings with General Constraints
CoRR, 2019 This paper focuses on two-sided matching where one side (a hospital or firm) is matched to the other side (a doctor or worker) so as to maximize a cardinal objective under general feasibility constraints. In a standard model, even though multiple doctors can be matched to a single hospital, a hospital has a responsive preference and a maximum quota ...
Yasushi Kawase, Atsushi Iwasaki
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Elevating Variational Quantum Semidefinite Programs for Polynomial Objectives [PDF]
QuantumMany practically important NP-hard optimization problems are inherently higher-order polynomial optimizations, which are typically addressed using approximation algorithms.
Iria W. Wang +5 more
doaj +1 more source
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source