Results 21 to 30 of about 1,610 (129)

2 5’ Untranslated Region-Based Detection of Genetically Diverse APPV Strains in US Midwest

Journal of Animal Science, 2022
Abstract Atypical porcine pestivirus (APPV), an RNA virus member of the Flaviviridae family, has been associated with congenital tremor in newborn piglets. Previous qPCR-based assays, targeting the polyprotein coding sequences of APPV, were unable to detect the virus in novel cases of congenital tremor originated from multiple swine ...
Christian Eaton, Kylee Sutton, Benny E Mote, Thomas E Burkey, Tudor Borza, J Dustin Loy, Daniel C Ciobanu   +6 more
openaire   +1 more source

Detection and localization of atypical porcine pestivirus in the testicles of naturally infected, congenital tremor affected piglets

Transboundary and Emerging Diseases, Volume 69, Issue 4, Page e621-e629, July 2022., 2022
Abstract Atypical porcine pestivirus (APPV) belongs to the genus Pestivirus within the family Flaviviridae. Recently, APPV has been identified as the causative agent of congenital tremor (CT) type AII. The disease is a neurological disorder that affects newborn piglets and is characterized by generalized trembling of the animals and often splay legs ...
Lilla Dénes, Inés Ruedas‐Torres, Anna Szilasi, Gyula Balka   +3 more
wiley   +1 more source

Investigation into an outbreak of Border disease virus in pigs in England

Transboundary and Emerging Diseases, Volume 69, Issue 4, Page 1698-1706, July 2022., 2022
Abstract Border disease (BD) was first reported in 1959 in lambs from the border region of England and Wales. The causative virus (BD virus; BDV) has since been identified in several other ruminant species and pigs. The virus is prevalent in sheep flocks of UK, Europe and USA and has potential to inflict substantial economic losses.
Akbar Dastjerdi, Rebecca Strong, S. Anna La Rocca, Mark Wessels, Julie Wessels, Kate Whitaker, Ben Strugnell, Susanna Williamson   +7 more
wiley   +1 more source

Analysis of necroptosis and its association with pyroptosis in organ damage in experimental pulmonary arterial hypertension

Journal of Cellular and Molecular Medicine, Volume 26, Issue 9, Page 2633-2645, May 2022., 2022
Abstract In this study, a role of cell loss due to necroptosis and its linkage with pyroptosis in organ damage under the conditions of pulmonary arterial hypertension (PAH) was examined. Monocrotaline (MCT) was used to induce PAH in Wistar rats, and depending on the severity of the disease progression, they were further divided into two subgroups: MCT ...
Izabela Jarabicová, Csaba Horváth, Eva Veľasová, Lenka Bies Piváčková, Jana Vetešková, Ján Klimas, Peter Křenek, Adriana Adameová   +7 more
wiley   +1 more source

The Logic of Illusion: Kant on the Reasons of Error

Theoria, Volume 87, Issue 6, Page 1468-1480, December 2021., 2021
Abstract In this paper, I reconstruct Immanuel Kant's theory of theoretical and practical error, and I situate it within the broader context of his transcendental philosophy. I thereby refer to his conception of dialectic as the logic of illusion (CpR, B 86) and to his concept of rationalizing.
Jörg Noller
wiley   +1 more source

Chimeric Flaviviral RNA−siRNA Molecules Resist Degradation by The Exoribonuclease Xrn1 and Trigger Gene Silencing in Mammalian Cells

ChemBioChem, Volume 22, Issue 21, Page 3099-3106, November 3, 2021., 2021
Chimeric molecules comprising an Xrn1‐resistant RNA motif (xrRNA) and a small interfering RNA (siRNA) duplex were engineered. The molecules self‐assemble in vitro, resist degradation by the conserved eukaryotic 5’ to 3’ exoribonuclease Xrn1, and trigger gene silencing in mammalian cells.
Cressida Harvey, Sven Klassa, Esteban Finol, Jonathan Hall, Alyssa C. Hill   +4 more
wiley   +1 more source

Porcine circovirus 3 (PCV‐3) as a causal agent of disease in swine and a proposal of PCV‐3 associated disease case definition

Transboundary and Emerging Diseases, Volume 68, Issue 6, Page 2936-2948, November 2021., 2021
Abstract Porcine circovirus 3 (PCV‐3) was discovered in 2015 using next‐generation sequencing (NGS) methods. Since then, the virus has been detected worldwide in pigs displaying several clinical–pathological outcomes as well as in healthy animals. The objective of this review is to critically discuss the evidence existing so far regarding PCV‐3 as a ...
Viviane Saporiti, Giovanni Franzo, Marina Sibila, Joaquim Segalés   +3 more
wiley   +1 more source

Congenital infection with atypical porcine pestivirus (APPV) is associated with disease and viral persistence [PDF]

Veterinary Research, 2017
In 2013, several Austrian piglet-producing farms recorded outbreaks of action-related repetitive myoclonia in newborn piglets ("shaking piglets"). Malnutrition was seen in numerous piglets as a complication of this tremor syndrome. Overall piglet mortality was increased and the number of weaned piglets per sow decreased by more than 10% due to this ...
Schwarz, Lukas, Riedel, Christiane, Högler, Sandra, Sinn, Leonie J., Voglmayr, Thomas, Wöchtl, Bettina, Dinhopl, Nora, Rebel-Bauder, Barbara, Weissenböck, Herbert, Ladinig, Andrea, Rümenapf, Till, Lamp, Benjamin   +11 more
openaire   +3 more sources

Three‐level hybrid modeling for systematic optimization of biocatalytic synthesis: α‐glucosyl glycerol production by enzymatic trans‐glycosylation from sucrose

Biotechnology and Bioengineering, Volume 118, Issue 10, Page 4028-4040, October 2021., 2021
Mechanism‐based kinetic models are broadly used to analyze enzymatic reactions, however their extension to actual conditions used in biocatalytic synthesis can be difficult. Here, the authors present a ‘closing of the gap’ hybrid modelling approach for the systematic reaction optimization of the glycosylation of glycerol catalyzed by sucrose ...
Alexander Sigg, Mario Klimacek, Bernd Nidetzky   +2 more
wiley   +1 more source

Dynamics of Infection of Atypical Porcine Pestivirus in Commercial Pigs from Birth to Market: A Longitudinal Study

Viruses, 2023
Atypical porcine pestivirus (APPV) was found to be associated with pigs demonstrating congenital tremors (CT), and clinical signs in pigs have been reproduced after experimental challenge.
Alexandra C. Buckley, Juan-Carlos Mora-Díaz, Ronaldo L. Magtoto, Amberly Van Hulzen, Franco Matias Ferreyra, Shollie M. Falkenberg, Luis G. Giménez-Lirola, Bailey L. Arruda   +7 more
doaj   +1 more source