Results 51 to 60 of about 796 (131)

Analysis of necroptosis and its association with pyroptosis in organ damage in experimental pulmonary arterial hypertension

Journal of Cellular and Molecular Medicine, Volume 26, Issue 9, Page 2633-2645, May 2022., 2022
Abstract In this study, a role of cell loss due to necroptosis and its linkage with pyroptosis in organ damage under the conditions of pulmonary arterial hypertension (PAH) was examined. Monocrotaline (MCT) was used to induce PAH in Wistar rats, and depending on the severity of the disease progression, they were further divided into two subgroups: MCT ...
Izabela Jarabicová, Csaba Horváth, Eva Veľasová, Lenka Bies Piváčková, Jana Vetešková, Ján Klimas, Peter Křenek, Adriana Adameová   +7 more
wiley   +1 more source

The Logic of Illusion: Kant on the Reasons of Error

Theoria, Volume 87, Issue 6, Page 1468-1480, December 2021., 2021
Abstract In this paper, I reconstruct Immanuel Kant's theory of theoretical and practical error, and I situate it within the broader context of his transcendental philosophy. I thereby refer to his conception of dialectic as the logic of illusion (CpR, B 86) and to his concept of rationalizing.
Jörg Noller
wiley   +1 more source

Chimeric Flaviviral RNA−siRNA Molecules Resist Degradation by The Exoribonuclease Xrn1 and Trigger Gene Silencing in Mammalian Cells

ChemBioChem, Volume 22, Issue 21, Page 3099-3106, November 3, 2021., 2021
Chimeric molecules comprising an Xrn1‐resistant RNA motif (xrRNA) and a small interfering RNA (siRNA) duplex were engineered. The molecules self‐assemble in vitro, resist degradation by the conserved eukaryotic 5’ to 3’ exoribonuclease Xrn1, and trigger gene silencing in mammalian cells.
Cressida Harvey, Sven Klassa, Esteban Finol, Jonathan Hall, Alyssa C. Hill   +4 more
wiley   +1 more source

Development of a one-step multiplex qRT–PCR assay for the detection of African swine fever virus, classical swine fever virus and atypical porcine pestivirus

BMC Veterinary Research, 2022
Background African swine fever virus (ASFV), classical swine fever virus (CSFV) and atypical porcine pestivirus (APPV) have caused great economic losses to the swine industry in China. Since coinfections of ASFV, CSFV and APPV occur in certain pig herds,
Huixin Liu, Kaichuang Shi, Jing Zhao, Yanwen Yin, Yating Chen, Hongbin Si, Sujie Qu, Feng Long, Wenjun Lu   +8 more
doaj   +1 more source

Porcine circovirus 3 (PCV‐3) as a causal agent of disease in swine and a proposal of PCV‐3 associated disease case definition

Transboundary and Emerging Diseases, Volume 68, Issue 6, Page 2936-2948, November 2021., 2021
Abstract Porcine circovirus 3 (PCV‐3) was discovered in 2015 using next‐generation sequencing (NGS) methods. Since then, the virus has been detected worldwide in pigs displaying several clinical–pathological outcomes as well as in healthy animals. The objective of this review is to critically discuss the evidence existing so far regarding PCV‐3 as a ...
Viviane Saporiti, Giovanni Franzo, Marina Sibila, Joaquim Segalés   +3 more
wiley   +1 more source

Three‐level hybrid modeling for systematic optimization of biocatalytic synthesis: α‐glucosyl glycerol production by enzymatic trans‐glycosylation from sucrose

Biotechnology and Bioengineering, Volume 118, Issue 10, Page 4028-4040, October 2021., 2021
Mechanism‐based kinetic models are broadly used to analyze enzymatic reactions, however their extension to actual conditions used in biocatalytic synthesis can be difficult. Here, the authors present a ‘closing of the gap’ hybrid modelling approach for the systematic reaction optimization of the glycosylation of glycerol catalyzed by sucrose ...
Alexander Sigg, Mario Klimacek, Bernd Nidetzky   +2 more
wiley   +1 more source

Performance of noninvasive tools for identification of minimal liver fibrosis in patients with hepatitis B virus infection

Journal of Clinical Laboratory Analysis, Volume 35, Issue 9, September 2021., 2021
ROC curves of noninvasive diagnostic methods for liver fibrosis (F0 vs. F1/2/3/4). Abstract Background Various noninvasive liver fibrosis assessment tools are available. Here, we evaluated the performance of the asparagine aminotransferase‐to‐platelet ratio index (APRI), the fibrosis‐4 index (FIB‐4), transient elastography (TE), and the globulin ...
Hong Zhang, XinXing Shi, Lin Wang, Yilan Zeng, Xintong Kang, Liang Huang   +5 more
wiley   +1 more source

Atypical Porcine Pestivirus as a Novel Type of Pestivirus in Pigs in China

Frontiers in Microbiology, 2017
Pestiviruses are highly variable RNA viruses. A growing number of novel pestiviruses has been discovered in domestic and wild species in the last two decades.
Jin Yuan, Zhiyong Han, Jun Li, Yunzhen Huang, Jiongfeng Yang, Hongxing Ding, Jingyuan Zhang, Mengjiao Zhu, Yangyi Zhang, Jiedan Liao, Mingqiu Zhao, Jinding Chen   +11 more
doaj   +1 more source

Fc-Mediated E2-Dimer Subunit Vaccines of Atypical Porcine Pestivirus Induce Efficient Humoral and Cellular Immune Responses in Piglets

Viruses, 2021
Congenital tremor (CT) type A-II in piglets is caused by an emerging atypical porcine pestivirus (APPV), which is prevalent in swine herds and a serious threat to the pig production industry.
Xujiao Ren, Ping Qian, Shudan Liu, Huanchun Chen, Xiangmin Li   +4 more
doaj   +1 more source

A Subunit Vaccine Based on E2 Protein of Atypical Porcine Pestivirus Induces Th2-type Immune Response in Mice

Viruses, 2018
An atypical porcine pestivirus (APPV) causing congenital tremor type A-II in piglets was identified in China in 2016. An increased number of cases of APPV have been reported in various countries all over the world since 2015.
Huawei Zhang, Wei Wen, Genxi Hao, Huanchun Chen, Ping Qian, Xiangmin Li   +5 more
doaj   +1 more source