Results 91 to 100 of about 10,910 (237)
Virtual screening using covalent docking to find activators for G245S mutant p53. [PDF]
PLoS ONE, 2018 TP53 is the most mutated gene in all cancers. The mutant protein also accumulates in cells. The high frequency of p53 mutations makes the protein a promising target for anti-cancer therapy.
Sara Ibrahim Omar +4 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer
Molecular & Cellular Oncology, 2017 The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors.
Kamil Lisek +2 more
doaj +1 more source
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C [PDF]
, 2019 Aim: The p53 cancer mutation Y220C creates a conformationally unstable protein with a unique elongated surface crevice that can be targeted by molecular chaperones.
Bauer, Matthias +9 more
core +1 more source
APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma [PDF]
Gut, 2015 Objectives p53 is a critical tumour suppressor and is mutated in 70% of oesophageal adenocarcinomas (OACs), resulting in chemoresistance and poor survival. APR-246 is a first-in-class reactivator of mutant p53 and is currently in clinical trials. In this study, we characterised the activity of APR-246 and its effect
Liu, DSH +11 more
openaire +3 more sources
Listening to Hong Kong children's perspectives through pretend play
British Educational Research Journal, EarlyView.Abstract Quality in early childhood education and care (ECEC) has become an increasing concern in recent years. The issue has been regularly discussed by different stakeholders. However, the rising concern regarding quality in ECEC has not seriously taken into account children's perspectives.
Suzannie K. Y. Leung
wiley +1 more source
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes [PDF]
, 2012 It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell.
Abate-Shen +229 more
core +2 more sources
Journal of Consumer Behaviour, EarlyView.ABSTRACT Grounded in ambivalence theories, this research examined factors shaping consumer ambivalence toward AI‐generated content and investigated differences between commercial and noncommercial contexts. As a preliminary study, sentiment analysis of Reddit data using a support vector machine (SVM) revealed that most consumer sentiment toward AI ...
Garim Lee +3 more
wiley +1 more source
Modulation of p53's transcriptional function by small molecules [PDF]
, 2011 p53 tumour suppressor is a transcriptional factor which induces apoptosis or growth arrest in response to stress thus eliminating damaged cells. p53 function is frequently abrogated in tumours either via inactivation mutations in the TP53 gene or by ...
Nikulenkov, Fedor
core +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background The optimal choice between balloon‐expandable (BE) and self‐expanding (SE) transcatheter heart valves (THVs) in patients with low‐flow low‐gradient aortic stenosis (LFLG AS) undergoing transcatheter aortic valve replacement (TAVR) remains unclear.
Nav Warraich +10 more
wiley +1 more source