Results 101 to 110 of about 10,910 (237)
Molecular & Cellular Oncology, 2017 Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as ...
Nicholas J. Clemons +3 more
doaj +1 more source
Rescue of mutant p53 family members by the low molecular weight compound PRIMA-1MET/ APR-246 [PDF]
, 2010 The tumor suppressor p53, guardian of the genome, is induced and activated by cellular stress signals such as DNA damage, hypoxia and activation of oncogenes. p53 upregulates downstream target genes, that are involved in cell cycle arrest, senescence,
Shen, Jinfeng
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1203-1216, April 2025.The 366 patients diagnosed with transthyretin amyloidosis cardiomyopathy (ATTR‐CM) were analyzed regarding their clinical characteristics in the first year after approval of tafamidis 61 mg for ATTR‐CM in Germany. Nearly two‐thirds of the patients were in an advanced disease stage and 64% met the key criteria of the “Transthyretin Amyloidosis ...
Richard J. Nies +23 more
wiley +1 more source
Clinical Hematology International, 2019 Patients with high-risk myeloid neoplasms, including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), are offered allogeneic hematopoietic cell transplantation (alloHCT) to improve the likelihood of long-term disease control. More than 50%
Katie Culos, Michael Byrne
doaj +1 more source
Obstetrical outcomes in pregnant patients following a gluten‐free diet: A prospective cohort study
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective Concerns have been raised about the nutritional adequacy of a gluten‐free (GF) diet during pregnancy, specifically in the absence of celiac disease, and its impact on fetal development. The objective of this study was to investigate the association between a GF diet during pregnancy and obstetrical outcomes, with further sensitivity ...
Amelia Srajer +8 more
wiley +1 more source
Die Interaktion zwischen p53 und p73 als molekulare Zielstruktur in der Tumortherapie [PDF]
, 2018 TP53 ist das in humanen Malignomen am häufigsten mutierte Tumorsuppressorgen (Kandoth et al. 2013). Mutationen des TP53-Gens führen meistens zur Expression von mutierten p53-Proteinen voller Länge, die neben einem Funktionsverlust durch onkogenes ...
Müller, Maximilian +1 more
core +1 more source
Decision Threshold Setting in Binary Classification Problems—A Behavioral Lens
Journal of Operations Management, EarlyView.ABSTRACT When binary classification models are wrong, managers face misclassification costs. Although false positive outcomes imply unnecessary mitigation efforts, false negative outcomes imply overlooking the class of interest. Humans calibrate these ai models supporting operational systems by adjusting the decision threshold that translates ...
Patrick Moder, Kai Hoberg, Felix Papier
wiley +1 more source
APR-246/PRIMA-1MetInhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium
Investigative Opthalmology & Visual Science, 2016 Squamous metaplasia is a common pathologic condition in ocular surface diseases for which there is no therapeutic medication in clinic. In this study, we investigated the effect of a small molecule, APR-246/PRIMA-1(Met), on squamous metaplasia in human conjunctival epithelium.Human conjunctival explants were cultured for up to 12 days under airlifting ...
Jing, Li +9 more
openaire +2 more sources
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose To investigate whether changing medical equipment suppliers in anterior cruciate ligament reconstruction (ACLR) influences surgical time, revision rates and subjective outcomes. Methods A retrospective cohort study was conducted using data from the Swedish Knee Ligament Registry (SKLR).
Dzan Rizvanovic +2 more
wiley +1 more source
Socioeconomic Deprivation and Vocal Handicap in Adults With Voice Disorders
The Laryngoscope, EarlyView.This study examined the relationship between socioeconomic deprivation and quality of life as measured by the Voice Handicap Index (VHI) in adults with voice disorders. Patients living with socioeconomic deprivation experienced greater voice‐related handicap from voice disorders than those from more affluent backgrounds, even when controlling for ...
Robert Brinton Fujiki +1 more
wiley +1 more source