Results 111 to 120 of about 10,910 (237)

Non-Coding RNAs in Ovarian Cancer [PDF]

, 2017
Ovarian cancer (OC) is the most lethal form of gynaecological cancer, with high- grade serous ovarian carcinoma (HGSOC) being the most common and the deadliest subtype.
Shah, Jaynish S
core  

A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues [PDF]

, 2015
Expression database. Column A contains the names of the 1099 TFs in humans. Columns B–BC provide the expression of the TFs in FPKM (fragments per kilobase of transcript per million), as calculated by Analysis Pipeline 1, across the 40 cell-types (52 ...
Borivoj Vojtesek, Christian Gluck, Isha Sethi, Kirsten Smalley, Michael J. Buck, Rose-Anne Romano, Satrajit Sinha   +6 more
core   +3 more sources

Individual movement modeling expands the power of migratory species observations: North Atlantic right whale case study

Limnology and Oceanography: Methods, EarlyView.
Abstract Understanding a population's distribution depends on observing the presence and movement of individuals throughout their range. For highly mobile marine species, these observations typically rely on high effort monitoring programs. Tracking enough individuals to understand trends in movement behavior is not always logistically feasible, and ...
Abigail M. Kreuser, Daniel E. Pendleton, Nicholas R. Record, Erin L. Meyer‐Gutbrod   +3 more
wiley   +1 more source

INVESTIGATION OF THE IMPACT OF THE R248Q MUTATION IN THE TP53 GENE ON THE INTERACTION OF THE P53 PROTEIN WITH THE DRUG APR-246 IN ACUTE MYELOID LEUKEMIA

Hematology, Transfusion and Cell Therapy
Objectives: The TP53 gene encodes the tumor suppressor protein p53, which is crucial in cancer biology. Mutations in TP53 occur in 10 to 20% of AML cases and are associated with an unfavorable prognosis and high refractoriness to chemotherapy.
LMF Bertoline, KC Lima, JA Machado-Neto
doaj   +1 more source

TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment [PDF]

, 2015
International audienceLung cancer is a serious public health problem. Although there has been significant progress in chemotherapy, non-small cell lung cancer is still resistant to current treatments, primarily because of the slow rate of cell ...
Boutard, Tifenn, Jacquot, Catherine, Le Palabe, Julie, Malleter, Marine, Roussakis, Christos, Rousseau, Bénédicte, Sakanyan, Vehary, Tomasoni, Christophe   +7 more
core   +5 more sources

Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Clinical outcome assessments (COAs) are essential for evaluating symptom severity, treatment response, and disease progression in Parkinson's disease (PD). As clinical knowledge evolves, it is necessary to revisit the recommendation status on the COAs to ensure their continued relevance and validity. Objectives To provide an updated
Evita Papathoma, Panagiota Tsitsi, Nirosen Vijiaratnam, Camila Aquino, Stephen R. Duma, Norbert Kovacs, Kigocha Lameck Okeng'o, Aparna Wagle Shukla, Roongroj Bhidayasiri, Tiago A. Mestre, Alvaro Sanchez Ferro, Alberto J. Espay, Michelle H.S. Tosin, Matej Skorvanek, Ioanna Markaki   +14 more
wiley   +1 more source

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance [PDF]

, 2012
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK).
Abell, Abken, Abken, Acquas, Ahn, Alessi DR, Amaravadi, Ambrosetti, Amler, Andre, Andreeff, Antoch, Arteaga, Atasoy, Auberger, Auberger, Auernhammer, Awada, Ayral-Kaloustian, Bakkenist, Ball, Bartek, Baselga, Basilico, Batist, Belvin, Belvin, Belvin, Bendell, Bendtzen, Benjamin, Berberich, Bernhardt, Bierer, Birnbaum, Bissell, Blagosklonny, Blagosklonny, Blagosklonny, Blagosklonny, Bonati, Bouscary, Bouscary, Bouscary, Brown, Brown, Calvo, Campbell, Caro, Cervello, Cervello, Cervello, Chang, Chapman, Chen, Chen, Cheng, Cheng, Choi, Citrin, Cloos, Cocco, Coin, Conejo-Garcia, Cook, Cook, Croasdell, Cross, D'Ambrosio, D'Orazi, Damia, Dammacco, Dang, Darnell, Darzynkiewicz, Davey, Davis, De Pover, Del Sal, Demetri, Dennis, Di Cristofano, Ding, Direnzo, Dong, Duronio, Eckhardt, Engelman, Engelman, Escudier, Evers, Falchook, Felip, Festuccia, Feun, Figlin, Finkel, Flachook, Flaherty, Flaherty, Fotedar, Foà, Friedman, Furman, Furman, Gadgeel, Gaither, Galle, Garcia-Echeverria, Garraway, Geissler, Gibbons, Giese, Gilmer, Glazer, Glynn, Gordon, Goutopoulos, Grant, Gray, Grever, Guan, Guan, Guichard, Ha, Haas-Kogan, Hall, Hallahan, Hammond, Hedley, Hedley, Heinemann, Heitman, Helin, Herlyn, Herlyn, Hollander, Hong, Horwitz, Houghton, Howell, Huang, Iozzo, James, Jang, Jendrossek, Jiang, Johnsen, Jongstra, Kaelin, Kaina, Kane, Kaufmann, Kaufmann, Kaufmann, Kelley, Khanna, Khwaja, Kimmelman, Knudsen, Koh, Konopleva, Kopelovich, Korn, Koromilas, Kotani, Kovalchuk, Kraft, Kraft, Kraft, Kramer, Kroemer, Kroemer, Kroemer, Lain, Landberg, Lannutti, Lawrence, Leber, Lee, Lin, Lippincott-Schwartz, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Liu, Lo, Lo, Lo, Longo, Lopez, Lu, Lu, Luedde, Macewan, Maestro, Maffucci, Maguire, Major, Marais, Marais, Marais, Marimuthu, Marks, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Mayer, Mayeux, McCann, McCubrey, McCubrey, McCubrey, McCubrey, McCubrey, McCubrey, McDaid, McDonald, Menendez, Menendez, Menendez, Merchant, Mercuri, Mijatovic, Milella, Mohammad, Montalto, Montalto, Munshi, Murata, Musgrove, Myers, Naing, Nakashima, Namchuk, Nathanson, Nawrocki, Nawrocki, Nicoletti, Nicoletti, Nijman, Nilsson, Nilsson, Noda, Noguchi, O'Dwyer, O'Dwyer, Oktay, Ouellet, Pachter, Padera, Padera, Panayotou, Pandolfi, Pandolfi, Pani, Park, Patel, Platanias, Platanias, Poli, Polman, Poroshina, Powis, Prives, Quart, Ramalingam, Reck, Ribas, Ribas, Ricart, Rieber, Roberts, Robertson, Rommel, Rosen, Rosen, Rosen, Rosen, Rosen, Roy, Roy, Ruggero, Rupprecht, Salmeron, Samuels, Sanchez, Sanders, Santoro, Sarkar, Sarkaria, Scaglioni, Schadendorf, Schellens, Schmidmaier, Schmidmaier, Schmidt, Schmidt, Schoffski, Schwartz, Scott, Sebolt-Leopold, Sebti, Selivanova, Sellers, Sellers, Sellers, Settleman, Sharan, Shaw, Shaw, Shellooe, Shields, Simeone, Simon, Sitzmann, Siu, Slingluff, Smalley, Smalley, Smalley, Smalley, Smalley, Smalley, Smith, Solary, Solit, Soria, Sotgia, Spratlin, Springer, Stathopoulos, Stegmeier, Stern, Stoeltzing, Stromblad, Stromblad, Su, Suh, Sun, Sutherland, Syed, Syljuasen, Tafuri, Tang, Theurkauf, Thompson, Thompson, Tran, Tse, Turhan, Valerie, van den Bent, van Montfort, van Montfort, Varticovski, Vassilev, Vazquez-Martin, Vidal, Vogt, Wacheck, Wang, Wang, Wang, Warmuth, Waterfield, Weinberg, Weiss, Weiss, Weissgerber, Weissman, Wessels, Wicha, Williams, Williams, Williamson, Winquist, Workman, Wrana, Xing, Yahalom, Yonezawa, Yu, Yung, Zacksenhaus, Zhang, Zhang, Zhang, Zhang, Zheng, Zhou, Zhou, Zopf   +402 more
core   +2 more sources

On the botanical history and nomenclature of the New World genus Piscidia (Fabaceae)

Nordic Journal of Botany, EarlyView.
Piscidia L. (Fabaceae) is a New World genus with nine recognized taxa (seven species and two varieties). The previous nomenclatural revisions, made in 1910 and in 1969, are revisited here. The names Derris grandifolia Heyde & Lux ex Donn.Sm. and P. cubensis Urb. required step II lectotypifications, with an epitype for the latter name.
Camila Sánchez‐ Vega, Kanchi Gandhi, Alfonso Delgado‐ Salinas, Benjamin Deloso, Javier Francisco‐ Ortega   +4 more
wiley   +1 more source

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets

Blood Advances, 2019
: Survival of patients with pediatric acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (allo-SCT) is mainly compromised by leukemia relapse, carrying dismal prognosis.
Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Kloetgen, Michael Gombert, Ute Fischer, Daniel Hein, Salih Demir, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Beat Bornhauser, Jean-Pierre Bourquin, Stefan Krause, Juergen Enczmann, Lüder Hinrich Meyer, Cornelia Eckert, Arndt Borkhardt, Roland Meisel   +29 more
doaj   +1 more source

State Capacity and Path Dependence in Cape Verde's Supreme Audit Institution

Public Administration and Development, EarlyView.
ABSTRACT This study examines state capacity and path dependence in the Supreme Audit Institution (SAI) of Cape Verde, focussing on the performance and governance of the Court of Auditors. Drawing on a mixed‐methods longitudinal design covering the period from 2010 to 2024, the analysis combines international governance indicators, documentary analysis,
Ana Lúcia Romão
wiley   +1 more source