Results 121 to 130 of about 10,910 (237)
Cell Death and DiseaseSNF2L encodes an ISWI chromatin remodeling factor that promotes gene transcription and is consistently elevated in cancers. Previous studies have shown that inhibiting SNF2L expression in cancer cells leads to significant growth suppression, DNA damage ...
Jiaguan Zhang +10 more
doaj +1 more source
Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells [PDF]
, 2017 Melittin, the main peptide present in bee venom, has been proposed as having potential for anticancer therapy; the addition of melittin to cisplatin, a first line treatment for ovarian cancer, may increase the therapeutic response in cancer treatment via
Alonezi, Sanad +10 more
core +1 more source
Progress in Photovoltaics: Research and Applications, EarlyView.This study introduces a self‐supervised machine learning approach integrating physics‐based principles to estimate open‐circuit voltage (voc$$ {v}_{oc} $$) degradation in photovoltaic systems using SCADA data. By combining clustering and regression algorithms, our method detects performance deviations without labelled datasets.
Sandra Riaño +4 more
wiley +1 more source
Respirology, EarlyView.A cardiopulmonary exercise testing‐derived summed score effectively predicted mortality or lung transplantation risk in newly diagnosed interstitial lung disease. Higher summed scores (2–5) were associated with markedly lower event‐free survival rates.
Yu‐Lin Tsai +6 more
wiley +1 more source
Translational OncologyNew treatments are urgently required for triple-negative breast cancer (TNBC). As TP53 is mutated in approximately 80% of TNBC, it is theoretically an attractive target for new drugs for this disease.
Subhasree Rajaram +4 more
doaj +1 more source
Shaping expectations, losing flexibility: A study of CEO promises as strategic communication tools
Strategic Management Journal, EarlyView.Abstract Research Summary CEO promises are powerful but understudied communication tools. We develop a dual‐mechanism framework theorizing that while CEO promises elevate stakeholder expectations, they simultaneously constrain strategic flexibility. We argue that CEO promise‐making is shaped by two competing pressures: making more promises when the ...
Majid Majzoubi +2 more
wiley +1 more source
Veterinary Record, EarlyView.Abstract Background Miscarriage, infertility and assisted fertility (MIAF) can profoundly impact physical and mental health. The aims of this study were to investigate how veterinary professionals’ work environments and employers impacted their experiences of MIAF and to identify how workplace experiences of MIAF could be improved.
Jenny Stavisky +3 more
wiley +1 more source
Molecular pathways and therapeutic targets in lung cancer [PDF]
, 2014 Lung cancer is still the leading cause of cancer death worldwide. Both histologically and molecularly lung cancer is heterogeneous. This review summarizes the current knowledge of the pathways involved in the various types of lung cancer with an emphasis
Bueno, Raphael +6 more
core +2 more sources
The impact of p53 mutation on tumor immune evasion: mechanistic insights and clinical implications
Frontiers in ImmunologyMutant p53(Mtp53) not only loses its canonical tumor-suppressive functions but also acquires oncogenic gain-of-function properties, positioning it as a central orchestrator in reshaping the tumor immune microenvironment.
Luo Liang, Weidong Wang
doaj +1 more source
Veterinary Record, EarlyView.Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins +8 more
wiley +1 more source