Results 131 to 140 of about 10,910 (237)

Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells [PDF]

, 2018
NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell. Here we show that in cancer cells NRF2 targets are selectively upregulated or repressed through a mutant p53-dependent mechanism.
Bell, Bergo, Bergo, Cescon, Chung, Crook, DeBerardinis, Del Sal, Del Sal, Dinkova-Kostova, Dubois, Eterno, Giordano, Holmgren, Hruban, Itoh, Jurado, Kim, Knight, Lathrop, Lee, Lee, Lisanti, Mak, Mechta-Grigoriou, Mondal, Morrison, Park, Pippione, Puga, Rotter, Santoro, Say, Schumacker, Schweiger, Singh, States, Szallasi, Tan, Thomson, Tonissen, Tonissen, Wang, Wang, Welch, Wiman, Wiman, Wiman, Yamamoto, Zhang, Zhang, Zhang, Zhang, Zhang   +53 more
core   +1 more source

Do cash or digital payment modalities affect community health worker performance? – a case study of a remote refugee settlement in Western Uganda

Global Health Action
Background There is inadequate evidence about the influence of digital and cash payment modalities on the performance of Community Health Workers (CHWs) in underserved communities, such as refugee settlements. Objective To compare the performance of CHWs
Michael T Wagaba, David Musoke, Charles Opio, Arthur Bagonza, Juliet Aweko, Hajarah Nakitende, Alex Mulyowa, Michael Ediau, Peter Waiswa, Elizabeth Ekirapa-Kiracho   +9 more
doaj   +1 more source

Audiological Characteristics in Vestibular Schwannoma Patients

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Vestibular schwannoma (VS) is a benign tumor that originates from the Schwann cells of the vestibular nerve sheath in the internal auditory canal. This retrospective study collected data from patients with VS who underwent surgical treatment to identify their demographic characteristics and audiometric features.
Shan Zeng, Yi‐Yun Lou, Hui‐Qian Yu, Wei‐Dong Zhao, Wen‐Yan Li   +4 more
wiley   +1 more source

Nocturnal neighbors: exploring residents' perceptions of urban wildlife related to animal traits identified by camera traps and literature

Wildlife Biology, EarlyView.
Wildlife in urban areas is often a source of conflict, yet relatively few efforts have been directed toward fostering coexistence in these human‐dominated landscapes. While previous research has focused on socio‐demographic factors influencing perceptions of wildlife, the role of specific animal traits in shaping acceptance remains underexplored.
Simon S. Moesch, Marufa Sultana, Geva Peerenboom, Ilse Storch   +3 more
wiley   +1 more source

Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants. [PDF]

Genes (Basel), 2023
Nagourney AJ, Gipoor JB, Evans SS, D'Amora P, Duesberg MS, Bernard PJ, Francisco F, Nagourney RA.   +7 more
europepmc   +1 more source

What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer? [PDF]

, 2019
Introduction: For decades, p53 was researched as a single protein with alterations described as mutants. The discovery of 12 human p53 isoforms expressed from 9 transcripts changed this perception, eloquently explaining the numerous roles p53 plays ...
Amaral JD, Arsic N, Bellanger S, Chakarov S, Chakarov S, Chakarov S, de Almeida AJPO, Flaman JM, Jean-Christophe Bourdon, Joruiz SM, Khalil HS, Khan D, Liam Hayman, Loughery J, Lowe J, Nikolai Zhelev, Olivier M, Oren M, Pan Y, Ray PS, Surget S, Victor V. Revin, Wajeeh Raza Chaudhry   +22 more
core   +2 more sources

Leaf longevity and structure, fruit mass and phenology in 52 cultivated varieties and wild accessions of olive

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Although phenology has long been recognized as a critical feature for the adaptation of organisms to their local environment, until recently, phenological events have seldom been considered in the broader context of trait‐based ecology.
Eric Garnier, Karim Barkaoui, Florent Alexandre, Sylvia Lochon‐Menseau, Bruno Bernazeau, Marie‐Laure Navas   +5 more
wiley   +1 more source

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. [PDF]

Cell Death Differ, 2023
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A.   +19 more
europepmc   +1 more source

Heating up parasitoid–host interactions: High temperature increased mortality of late‐instar braconid larvae and reduced ladybird recovery rate

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract With ongoing climate change, temperature‐dependent outcomes of host–parasitoid interactions can affect ecosystem functioning and key ecosystem services such as biological control. However, most studies addressing the impacts of temperature on host–parasitoid systems are
Florencia Baudino, Barbora Žabová, Michal Řeřicha, Michal Knapp   +3 more
wiley   +1 more source

Regulation and therapy: the role of ferroptosis in DLBCL

Frontiers in Pharmacology
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of B-cell non-Hodgkin’s lymphoma (NHL), up to 30%–40% of patients will relapse and 10%–15% of patients have primary refractory disease, so exploring new treatment options is necessary ...
Yifan Wang, Yifan Wang, Zhengmei He, Zhengmei He, Xinyu Dong, Xinyu Dong, Yiming Yao, Yiming Yao, Qiuni Chen, Qiuni Chen, Yuye Shi, Yuye Shi, Yuan Deng, Yuan Deng, Quane Zhang, Quane Zhang, Liang Yu, Liang Yu, Liang Yu, Chunling Wang, Chunling Wang, Chunling Wang   +21 more
doaj   +1 more source