Results 151 to 160 of about 10,910 (237)

LT1-3, a Slit2-Derived Peptide, Exhibits Anti-Tumor Activity and Improves Cisplatin Therapy

Cells
The Slit2/Robo signaling pathway acts as a tumor suppressor in various cancers. This study identified an 8-amino acid peptide, LT1-3, derived from the Slit2 LamG domain, and demonstrated its ability to inhibit lung cancer cell proliferation and invasion ...
Ting-Chien Wu, Chen-Yi Liao, Yu-Ying Lin, Shu-Ming Chuang, Szu-Yu Liu, Chi-Hsiang Wang, Shang-Er Su, Siang-Wei Wu, Ling-I Wang, Wei-Ting Chen, Sheng-Wen Cheng, Yu-Tang Huang, Yao-Bin Zheng, Cheng-Yen Chuang, Feng-Di Lung, Jinghua Tsai Chang   +15 more
doaj   +1 more source

Does the total consumption model apply to cannabis use?

Addiction, EarlyView.
Abstract Aims To test whether the total consumption model and its extension, the theory of collectivity, apply to adolescent cannabis use. We estimated: (1) whether the distribution of cannabis use frequency was stable over time; (2) whether changes in average cannabis use were mirrored across consumption quantiles; and (3) whether higher average use ...
Thor Norström, Håkan Leifman
wiley   +1 more source

Faith, gender and financial investment: Providence and Presbyterianism in Scotland and abroad

Asia‐Pacific Economic History Review, EarlyView.
Abstract Mid‐nineteenth century fictional representations of misdirected investment by widows and clergy position them as ignorant in financial matters and hence pitiable. While scholars have recognised female agency in nineteenth century commerce, insufficient attention has been paid to religious belief in financial decision‐making.
Jennifer Jones, Susan Poole
wiley   +1 more source

Efficacy of glutathione inhibitor eprenetapopt against the vulnerability of glutathione metabolism in SMARCA4-, SMARCB1- and PBRM1-deficient cancer cells

Scientific Reports
Mutation of genes related to the SWI/SNF chromatin remodeling complex is detected in 20% of all cancers. The SWI/SNF chromatin remodeling complex comprises about 15 subunits and is classified into three subcomplexes: cBAF, PBAF, and ncBAF. Previously, we
Mariko Sasaki, Hideaki Ogiwara
doaj   +1 more source

The Multifaceted Role of p53 in Cancer Molecular Biology: Insights for Precision Diagnosis and Therapeutic Breakthroughs

Biomolecules
The protein p53, often referred to as the “guardian of the genome,” is essential for preserving cellular balance and preventing cancerous transformations.
Bolong Xu, Ayitila Maimaitijiang, Dawuti Nuerbiyamu, Zhengding Su, Wenfang Li   +4 more
doaj   +1 more source

Targeted Therapy with PI3K, PARP, and WEE1 Inhibitors and Radiotherapy in HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy while Effects with APR-246 Are Limited. [PDF]

Cancers (Basel), 2022
Byskata K, Lukoseviciute M, Tuti F, Zupancic M, Kostopoulou ON, Holzhauser S, Dalianis T.   +6 more
europepmc   +1 more source

Information flow and the adoption of soil‐improving and water conservation measures, and household welfare: Insights from a randomized controlled trial in Uganda

American Journal of Agricultural Economics, EarlyView.
Abstract Extension services are designed to facilitate the flow of information from researchers to farmers. However, information failures continue to impede the diffusion of soil‐improving and water conservation technologies in Sub‐Saharan African countries. We use a randomized controlled trial (RCT) to examine the impact of an extension‐based campaign
Esther Gloria Mbabazi, Awudu Abdulai, Enoch M. Kikulwe, Elisabetta Gotor   +3 more
wiley   +1 more source

PRIMA-1 Analog APR-246 [PDF]

, 2020
openaire   +1 more source

Time of day of cardiac surgery and postoperative outcomes in the UK: a secondary analysis of linked national datasets

Anaesthesia, EarlyView.
Summary Introduction Uncertainty remains regarding whether the time of day that cardiac surgery is performed affects postoperative outcomes or if the observed variation can be explained by patient or surgical factors. Methods A secondary analysis of prospectively collected data was conducted to examine the association between time of cardiac surgery ...
Gareth Kitchen, Karen Thomas, Tim Felton, Hannah Durrington, John Blaikley, Stuart W. Grant, David Harrison, Peter McGuigan, Kathryn Rowan, Anthony Wilson, Danny McAuley, Paul Dark   +11 more
wiley   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source