Results 161 to 170 of about 10,910 (237)

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance [PDF]

, 2016
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing owing to a lack of robust stratification methods.
Abdullahi, Z, Achilleos, A, Ang, Y, Bagwan, I, Barbour, AP, Barr, H, Beardsmore, D, Berrisford, R, Bornschein, J, Bower, L, Bunting, D, Chang, F, Cheong, E, Chettouh, H, Cluroe, A, Collier, P, Contino, G, Crawte, J, Crichton, C, Davies, A, Davies, J, De La Rue, R, De Silva, N, Edwards, PAW, Eldridge, MD, Elliott, RF, Eneh, V, Fitzgerald, RC, Ford, H, Francies, HE, Galeano-Dalmau, N, Garnett, MJ, Gossage, J, Grabowska, A, Grehan, N, Haidry, R, Harden, C, Hardwick, R, Hayes, SJ, Hupp, TR, Igali, L, Kaye, P, Kumar, B, Lagergren, J, Lewis, M, Li, X, Lishman, S, Lovat, L, Lynch, AG, Macrae, S, Malhotra, S, Miremadi, A, Noble, F, Noorani, A, Nutzinger, B, O'Donovan, M, O'Neill, JR, Oakes, S, Old, O, Owsley, J, Parsons, SL, Preston, SR, Ross-Innes, C, Sanders, G, Saunders, J, Save, V, Scott, M, Secrier, M, Shepherd, N, Skipworth, RJE, Smith, L, Smith, ML, Soomro, I, Sothi, S, Suortamo, S, Taniere, P, Tavaré, S, Tucker, O, Turkington, R, Underwood, T, Waddell, N, Weaver, J, Welch, I, Yang, TP, Zylstra, J   +84 more
core  

Beyond performance: Emotions before and after semi‐high‐stakes mathematics testing among school‐aged students

British Journal of Educational Psychology, EarlyView.
Abstract Background Previous research has shown that testing differs significantly from other classroom activities and is associated with heightened negative emotions and lower levels of positive emotions. However, relatively little is known about students' emotions surrounding testing, particularly in higher‐stakes assessment settings. Aims This study
Reetta Kyynäräinen, Santeri Holopainen, Jari Metsämuuronen, Umar Bin Qushem, Mikko‐Jussi Laakso, Katarina Alanko   +5 more
wiley   +1 more source

CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer. [PDF]

Int J Mol Sci, 2021
Makhale A, Nanayakkara D, Raninga P, Khanna KK, Kalimutho M.   +4 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity in Cerrena unicolor 87613

Microbiology Spectrum
The white rot fungus Cerrena unicolor 87613 has been previously shown to be a promising resource in laccase production, an enzyme with significant biotechnological applications. Conventional methods face technical challenges in improving laccase activity.
Long-Bin Zhang, Ting-Ting Qiu, Xiu-Gen Qiu, Wu-Wei-Jie Yang, Xiu-Yun Ye, Chun Meng   +5 more
doaj   +1 more source

APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation. [PDF]

Br J Cancer, 2021
Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y.   +11 more
europepmc   +1 more source

ACTH Stimulation Testing Is Often Unnecessary After Appropriate Patient Preparation Prior to Screening Cortisol Measurement

Clinical Endocrinology, EarlyView.
ABSTRACT Context Screening morning serum cortisol is used to select patients for ACTH stimulation testing to diagnose adrenal insufficiency (AI) but may be affected by pre‐analytical factors. Careful consideration to discontinue confounding medications beforehand may preclude the need for subsequent stimulation testing.
Christopher J. Symonds, Alexander A. Leung, Gregory A. Kline   +2 more
wiley   +1 more source

What Linked Data Can Tell Us About the Increasing Numbers of Children Entering Public Care

Child &Family Social Work, EarlyView.
ABSTRACT The number of children in public care in Wales, UK, rose from the mid‐1990s to 2021. It is unclear if this change was related to increases in risk factors in parents, changes in the impact of risk factors, or changing policies and practices.
Nell Warner, Donald Forrester, Jonathan Scourfield, Rebecca Cannings‐John, Ann John   +4 more
wiley   +1 more source

Long‐term follow‐up and combined Phase 2 results of eprenetapopt and azacitidine in patients with TP53 mutant MDS/AML

HemaSphere
TP53 gene mutations (mTP53) represent a distinct molecular cohort with poor outcomes. Eprenetapopt (APR‐246) is a novel, first‐in‐class small molecule that reactivates p53 and targets cellular redox balance, ultimately inducing apoptosis and ferroptosis ...
David A. Sallman, Rami S. Komrokji, Amy E. Dezern, Marie Sebert, Guillermo Garcia‐Manero, Ramy Rahmé, Eric S. Winer, Jacqueline Lehmann‐Che, Gail J. Roboz, Isabelle Madelaine, Mikkael A. Sekeres, Pierre Peterlin, Onyee Chan, Odile Beyne‐Rauzy, Andrew Kuykendall, Christian Recher, Amy McLemore, Aspasia Stamatoullas, Ling Zhang, Lise Willems, Qianxing Mo, Emmanuel Raffoux, Lisa Nardelli, Céline Berthon, Najla H. Al Ali, Bruno Quesnel, Eric Padron, Hagop M. Kantarjian, Alan F. List, Lionel Ades, Jeffrey E. Lancet, Pierre Fenaux, Thomas Cluzeau   +32 more
doaj   +1 more source

Mutant p53 talks to proteasomes—is there a feedback loop between Nrf2 and mutant p53? [PDF]

, 2016
Acedo Nunez, P, Zawacka-Pankau, J
core   +1 more source