Results 41 to 50 of about 10,910 (237)

Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1^MET/APR-246. [PDF]

Cell Death Dis, 2020
AbstractP63 is a major transcription factor regulating skin development and homeostasis. It controls many genes involved in cell proliferation, adhesion, and early differentiation. P63 is mutated in several rare syndromes called p63-related ectodermal dysplasia syndromes (ED).
Aberdam E, Roux LN, Secrétan PH, Boralevi F, Schlatter J, Morice-Picard F, Sol S, Bodemer C, Missero C, Cisternino S, Aberdam D, Hadj-Rabia S.   +11 more
europepmc   +5 more sources

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells. [PDF]

Cell Death Dis, 2015
AbstractTwo main causes of platinum resistance are mutation in the tumor suppressor gene TP53 and drug-induced increase in intracellular glutathione concentration. Mutations in TP53 occur in about 50% of human tumors. APR-246 (PRIMA-1MET) is the first clinical-stage compound that reactivates mutant p53 and induces apoptosis.
Mohell N, Alfredsson J, Fransson Å, Uustalu M, Byström S, Gullbo J, Hallberg A, Bykov VJ, Björklund U, Wiman KG.   +9 more
europepmc   +5 more sources

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma [PDF]

, 2018
Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors.
Daylan, Ayse Ece Cali, Del Vecchio, Annachiara, Espinoza, Carlos, Fabo, Tania, Fearon, Eric R., Feng, Ying, Galbán, Stefanie, Halbrook, Christopher J., Karim, Saadia A., Kovalenko, Ilya, Kremer, Daniel M., Kumar-Sinha, Chandan, Lee, Ho-Joon, Ljungman, Mats, Lyssiotis, Costas A., Magnuson, Brian, Morton, Jennifer P., Pasca di Magliano, Marina, Schofield, Heather K., Yan, Wei, Zeller, Jörg   +20 more
core   +1 more source

Figure S10 from APR-246 enhances colorectal cancer sensitivity to radiotherapy

, 2023
<p>Supplementary figure 10</p>
Xiao-Feng Sun, Zengren Zhao, Peter Larsson, Anna Ljusberg, Carolin Jönsson, Jonas Burman, Lasse D. Jensen, Jing Zhang, Bin Luo, Chuanwen Fan, Xuqin Xie   +10 more
openaire   +1 more source

Prima-1 and APR-246 in Cancer Therapy

Klinicka onkologie, 2018
p53 is the most mutated protein in cancer and the reactivation of its inactive mutated form represents one possibility for antitumor therapy. Reactivation leads to the initiation of apoptosis followed by the suppression of the malignant phenotype. Prima-1 and its methylated form Prima-1Met (also called APR-246) are compounds capable of reactivating ...
Pavlína, Zatloukalová, Michaela, Galoczová, Bořivoj, Vojtěšek   +2 more
openaire   +2 more sources

Figure S2 from APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy

, 2023
<p>Supplementary figure 2</p>
Xiao-Feng Sun, Zengren Zhao, Peter Larsson, Anna Ljusberg, Carolin Jönsson, Jonas Burman, Lasse D. Jensen, Jing Zhang, Bin Luo, Chuanwen Fan, Xuqin Xie   +10 more
openaire   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Figure S7 from APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy

, 2023
<p>Supplementary figure 7</p>
Xiao-Feng Sun, Zengren Zhao, Peter Larsson, Anna Ljusberg, Carolin Jonsson, Jonas Burman, Lasse D. Jensen, Jing Zhang, Bin Luo, Chuanwen Fan, Xuqin Xie   +10 more
openaire   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1. [PDF]

Oncogene, 2018
TP53 mutations frequently occur in head and neck squamous cell carcinoma (HNSCC) patients without human papillomavirus infection. The recurrence rate for these patients is distinctly high. It has been actively explored to identify agents that target TP53 mutations and restore wild-type (WT) TP53 activities in HNSCC.
Hang W, Yin ZX, Liu G, Zeng Q, Shen XF, Sun QH, Li DD, Jian YP, Zhang YH, Wang YS, Quan CS, Zhao RX, Li YL, Xu ZX.   +13 more
europepmc   +4 more sources