Supplementary Data from APR-246 enhances colorectal cancer sensitivity to radiotherapy
, 2023 <p>p53Wt_log2FC of genes</p>
Xiao-Feng Sun +10 more
openaire +1 more source
Potential Role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface [PDF]
, 2015 The integrity and normal function of the corneal epithelium are crucial for maintaining the cornea's transparency and vision. The existence of a cell population with progenitor characteristics in the limbus maintains a dynamic of constant epithelial ...
Casaroli Marano, Ricardo Pedro +4 more
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Supplementary tables from APR-246 enhances colorectal cancer sensitivity to radiotherapy
, 2023 <p>Supplementary tables</p>
Xiao-Feng Sun +10 more
openaire +1 more source
Frontiers in Oncology, 2019 Prima-1Met (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53.
Benoit Tessoulin +15 more
doaj +1 more source
Genetic and epigenetic studies of acute myeloid leukemia and therapeutic possibilities [PDF]
, 2020 Acute myeloid leukaemia (AML) is malignant tumour that forms in the bone marrow and arises from immature myeloid progenitors. Consequently, this leads to excessive accumulation of dysfunctional blast cells and lack of normal blood cells. The molecular
Mujahed, Huthayfa
core +1 more source
Supplementary Figure Legends from APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy
, 2023 <p>Supplementary Figure Legends</p>
Xiao-Feng Sun +10 more
openaire +1 more source
Restoring p53 Function in Head and Neck Squamous Cell Carcinoma to Improve Treatments
Frontiers in Oncology, 2022 TP53 mutation is one of the most frequent genetic alterations in head and neck squamous cell carcinoma (HNSCC) and results in an accumulation of p53 protein in tumor cells.
Tycho de Bakker +10 more
doaj +1 more source
Recent discoveries in the cycling, growing and aging of the p53 field [PDF]
, 2012 The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed.
Demidenko, Zoya N., McCubrey, James A.
core +2 more sources
Small molecules as research tools for studying the biology of the tumour suppressor p53 [PDF]
, 2011 p53 is a potent tumour suppressor that is inactivated in the majority, if not all human cancers. In about 50% of the cases, the gene is mutated and in the rest it is rendered inactive mainly by deregulation of its negative regulators such as Hdm2 and
Spinnler, Clemens
core +1 more source
SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than TP53 Mutation Status
Molecular Cancer Therapeutics, 2021 Abstract APR-246 (eprenetapopt) is in clinical development with a focus on hematologic malignancies and is promoted as a mutant-p53 reactivation therapy. Currently, the detection of at least one TP53 mutation is an inclusion criterion for patient selection into most APR-246 clinical trials.
Kenji M. Fujihara +11 more
openaire +2 more sources