Results 71 to 80 of about 10,910 (237)

APR-246/PRIMA-1MET reverse squamous metaplasia in human conjunctival epithelium [PDF]

, 2015
目的探讨APR-246/PRIMA-1MET对人结膜鳞状上皮化生（squamousmetaplasia，SM）的影响及研究其相关作用机制。 方法结膜组织以不同浓度的APR-246/PRIMA-1MET（0μM，3μM，15μM）空气暴露培养不同时间（4，8，12天）。HE染色检测结膜上皮的形态改变；免疫组织化学染色检测结膜上皮特异性功能相关基因的表达；实体显微镜观察测算结膜周边新生上皮细胞的数量和速度；免疫荧光染色和实时荧光PCR检测上皮增殖及分化状态和Wnt信号通路相关基因的表达 ...
李晶
core  

Integrating Patient‐Reported Quality Measures in SLE: Development of the American College of Rheumatology Implementation Guide

Arthritis Care &Research, Accepted Article.
Objective To support high‐quality, patient‐centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence‐based measures incorporating clinical and patient‐reported outcomes measures (PROMs). Using the Consolidated Framework for Implementation Research (CFIR), we conducted semi‐structured interviews ...
Catherine Nasrallah, Cherish Wilson, Christine Hariz, Christie M Bartels, Shanthini Kasturi, Wambui Machua, Amy Bennett, Kate Chiseri, Allison Plitman, Starla Hairston Blanks, April Jorge, Patti Katz, Jinoos Yazdany, Shivani Garg   +13 more
wiley   +1 more source

Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment [PDF]

, 2018
Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added value to predict the recurrence risk of high risk GIST besides mitotic count, primary location and size.
Büttner, Reinhard, Duensing, Anette, Eriksson, Mikael, Hartmann, Wolfgang, Huss, Sebastian, Ihle, Michaela Angelika, Jeske, Wiebke, Joensuu, Heikki, Merkelbach-Bruse, Sabine, Reichardt, Peter, Schildhaus, Hans-Ulrich, Sihto, Harri, Sundby Hall, Kirsten, Wardelmann, Eva   +13 more
core   +7 more sources

An open-label phase I dose-finding study of APR-246 in hematological malignancies. [PDF]

Blood Cancer J, 2016
Deneberg S, Cherif H, Lazarevic V, Andersson PO, von Euler M, Juliusson G, Lehmann S.   +6 more
europepmc   +4 more sources

EVALUATING THE THERAPEUTIC EFFICACY OF RESTORING WILD-TYPE P53 ACTIVITY IN P53-MUTANT TUMORS [PDF]

, 2017
The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, TP53 mutations have been shown to be remarkably predictive of refractoriness to treatment,
Larsson, Connie A
core   +1 more source

Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial-Like Cells [PDF]

, 2017
Cornea is a clear outermost layer of the eye which enables transmission of light onto the retina. The transparent corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in LSCs deficiency (LSCD).
Alharthi, S, Armstrong, L, Bojic, S, Buck, H, Collin, J, Figueiredo, FC, Kamarudin, TA, Lako, M, Shortt, A, Yu, M   +9 more
core   +1 more source

Ovarian cancers with low CIP2A tumor expression constitute an APR-246 sensitive disease subtype [PDF]

, 2021
AbstractIdentification of ovarian cancer (OvCa) patient subpopulations with increased sensitivity to targeted therapies could offer significant clinical benefit. We report that 22% of the high grade OvCa tumors at diagnosis express CIP2A oncoprotein at low levels. CIP2AlowOvCa tumors have significantly lower likelihood of disease relapse after standard
Anna N. Cvrljevic, Umar Butt, Kaisa Huhtinen, Tove J. Grönroos, Camilla Böckelman, Heini Lassus, Katja Kaipio, Tiina Arsiola, Teemu D. Laajala, Denise C. Connolly, Ari Ristimäki, Olli Carpen, Jeroen Pouwels, Jukka Westermarck   +13 more
openaire   +1 more source

Degradation Mechanisms in PEM Water Electrolysis: Diagnosis and Impact

Advanced Materials Technologies, EarlyView.
This review provides an analysis of degradation mechanisms in proton electrolyte membrane water electrolyzers (PEMWE), focusing on all key components. It discusses diagnostic and measurement techniques for evaluating degradation, less‐studied mechanisms, and an expert survey.
Annik Bernhardt, Katja Lange, Robert Göckeritz, Erik Grunwald, Angelika Hähnel, Alexander Müller, Volker Naumann, Sistan Rasuli, Wolfram Münchgesang, Bruno G. Pollet, Kerstin Witte‐Bodnar, Klemens Ilse   +11 more
wiley   +1 more source

Pattern of p53 protein expression is predictive for survival in chemoradiotherapy-naive esophageal adenocarcinoma [PDF]

, 2017
Introduction: TP53 mutations are considered to be the driving factor in the initiation of esophageal adenocarcinoma (EAC). However, the impact of this gene and its encoded protein as a prognostic marker has not been definitely established yet.
Biermann, K. (Katharina), Dinjens, W.N.M. (Winand), Dorssers, L.C.J. (Lambert), Doukas, M. (Michael), Jones, D. (David), Kate, F.J.C. (Fiebo) ten, Lanschot, J.J.B. (Jan) van, Looijenga, L.H.J. (Leendert), Nieboer, D. (Daan), Suzuki, L. (Lucia), Wijnhoven, B.P.L. (Bas)   +10 more
core   +4 more sources

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source