Results 101 to 110 of about 1,914,713 (386)

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

open access: yesFrontiers in Oncology, 2016
TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism, and other processes. Missense mutations in TP53 abolish specific DNA binding of
V. Bykov   +5 more
semanticscholar   +1 more source

An Equilibrium Model of Lumpy Housing Investment [PDF]

open access: yes
We formulate and solve a dynamic general equilibrium model with heterogeneous agents and lumpy housing adjustment at the household level. We use the model to ask a simple question: how does the microeconomic lumpiness of housing adjustment affect the ...
Marina Pavan, Matteo Iacoviello
core  

Performance Characteristics of Anti–Collagen II Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective Relapsing polychondritis (RP) is a rare disease defined by recurrent cartilaginous inflammation. Anti–collagen II (Col2) antibodies have been proposed as a diagnostic biomarker for RP, but their performance characteristics are not well defined.
Karyssa Stonick   +6 more
wiley   +1 more source

An open-label phase I dose-finding study of APR-246 in hematological malignancies

open access: yesBlood Cancer Journal, 2016
Mutations in the TP53 tumor suppressor gene occur at different frequencies in a variety of human malignancies. 1 TP53 encodes a DNA-binding transcription factor that induces cell growth arrest, senescence and cell death by apoptosis upon cellular stress,
Stefan Deneberg   +7 more
semanticscholar   +1 more source

Evaluation of a novel EHR sidecar application to display RA clinical outcomes during clinic visits: results of a stepped‐wedge cluster randomized pragmatic trial

open access: yesArthritis Care &Research, Accepted Article.
Objective We developed a novel EHR sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk   +16 more
wiley   +1 more source

Effects of an antler point restriction on deer hunter perceptions and satisfaction in Missouri

open access: yesWildlife Society Bulletin, 2018
Antler point restrictions (APR), intended to create an older male age structure of white‐tailed deer (Odocoileus virginianus), have been implemented in many states, but effects of APR on hunters’ satisfaction and activities often have not been measured ...
Lonnie P. Hansen   +5 more
doaj   +1 more source

Helping Consumers to Evaluate Annual Percentage Rates (APR) on Credit Cards

open access: yesJournal of experimental psychology. Applied, 2019
To help consumers make informed decisions, regulators often impose disclosure requirements on financial institutions. However, disclosures may not be informative for consumers if they contain difficult-to-evaluate attributes, such as annual percentage ...
Alycia Chin, W. Bruine de Bruin
semanticscholar   +1 more source

Direct and Indirect Complementarity between Workplace Reorganization and New Technology [PDF]

open access: yes
We link survey and balance sheet data to investigate the extent of complementarity between the introduction of new technology and changes in workplace practices.
Alessandro Gaj   +2 more
core  

MYCOPHENOLATE MOFETIL TREATMENT REDUCES THE RISK OF TREATMENT ESCALATION DUE TO VASCULAR COMPLICATIONS IN LIMITED CUTANEOUS SYSTEMIC SCLEROSIS: EMULATION OF A TARGET TRIAL FROM ITALIAN RHEUMATOLOGY SOCIETY SPRING REGISTRY

open access: yesArthritis Care &Research, Accepted Article.
Objective Mycophenolate Mofetil (MMF) use in limited cutaneous systemic sclerosis (lcSSc) is relatively uncommon due to the lower fibrotic burden and the predominance of the vascular complications. In vitro observations and clinical data from transplanted patients suggest a protective effect of MMF on endothelial function.
Enrico De Lorenzis   +77 more
wiley   +1 more source

Il rilievo con drone nei centri storici

open access: yesGEOmedia, 2016
The survey with an UAV in the city centre for a research project of the University of L'Aquila has been started the use of UAV technology in some areas damaged by the earthquake of 2009.
Zaira Baglione
doaj  

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