Results 191 to 200 of about 1,914,713 (386)

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Intersectional Disparities in Digital Health and Mental Health Service Use Among US Youth During the COVID-19 Pandemic: Cross-Sectional Analysis of a National Survey

Journal of Medical Internet Research
BackgroundSexual minority youth, particularly sexual minority youth of color, report elevated mental health challenges and persistent barriers to care.
Meghan Romanelli, Carolina Vélez-Grau, Julien Rouvere, Sarah F Porter   +3 more
doaj   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

The Cowl - v.16 - n.19 - Apr 28, 1954 [PDF]

, 1954
The Cowl - student newspaper of Providence College. Volume 16, Number 19 - Apr 28, 1954, 1951.

core   +1 more source

Soft Robotics and Advanced Technologies for Minimally Invasive Bioprinting: The Future of Internal Organ Repair

Advanced Science, EarlyView.
This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu, Nhu An Phan, Sy Trung Ngo, Minh Tri Phan, Thanh‐An Truong, Chi Cong Nguyen, Phuoc Thien Phan, Hoang‐Phuong Phan, Thanh Nho Do, Mai Thanh Thai   +9 more
wiley   +1 more source

Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Scientific Reports
Low anterior resection (LAR) and abdominoperineal resection (APR) are the two main surgical procedures after preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer.
Jochen Gaedcke, Malte Sahrhage, Marcel Ebeling, Azadeh Azizian, Felix Rühlmann, Markus Bernhardt, Marian Grade, Wolf Otto Bechstein, Christoph-Thomas Germer, Robert Grützmann, Pompiliu Piso, Ralf-Dieter Hofheinz, Ludger Staib, Tim Beißbarth, Rebekka Kosmala, Emmanouil Fokas, Claus Rödel, Michael Ghadimi, The German Rectal Cancer Study Group   +18 more
doaj   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Southern California alumni review, vol. 17, no. 8 (1936 Apr.)

, 2021
Unknown
openalex   +1 more source

Southern California alumni review, vol. 27, no. 8 (1946 Apr.)

, 2021
Unknown
openalex   +1 more source

Dual‐Band Modulation of Emissivity and Solar Transmittance Through Chemical Composition‐Tuned Asymmetric Layer‐by‐Layer Assembly

Advanced Science, EarlyView.
An unconventional asymmetric Layer‐by‐Layer (LbL) assembly technique was developed to fabricate a Fabry‐Pérot (F‐P) resonator, which enhances luminous transmittance (Tlum) and enables dual‐band modulation in both the near‐infrared (NIR) and mid‐infrared (MIR) regions.
Hebing Hu, Zhengui Zhou, Guanya Wang, Xiaofei Li, Yun Meng, Tao Xu, Xiao'e Jia, Hao Yu, Yuhan Wang, Jiarui Wang, Yi Long   +10 more
wiley   +1 more source