Results 31 to 40 of about 1,914,713 (386)
Haematologica, 2019 Myelodysplastic syndromes and acute myeloid leukemia with TP53 mutations are characterized by frequent relapses, poor or short responses, and poor survival with the currently available therapies including chemotherapy and 5-azacitidine (AZA).
N. Maslah +16 more
semanticscholar +1 more source
APR Financial Stress Scale: Development and Validation of a Multidimensional Measurement
Journal of Financial Therapy, 2020 People usually experience financial stress in managing their financial resources. Despite financial stress’ importance in life outcomes and the need for a comprehensive and theory-based measurement of the construct, few studies have addressed the ...
Wookjae Heo, S. Cho, Philseok Lee
semanticscholar +1 more source
Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma
Cancers, 2021 Simple Summary Preclinical analyses identified APR-246 as a potent treatment option for neuroblastoma. However, a specific mode of action, sufficient biomarkers and promising combination partners are still missing.
Michael Müller +16 more
semanticscholar +1 more source
SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than TP53 Mutation Status
Molecular Cancer Therapeutics, 2020 APR-246 (eprenetapopt) is in clinical development with a focus on hematologic malignancies and is promoted as a mutant-p53 reactivation therapy. Currently, the detection of at least one TP53 mutation is an inclusion criterion for patient selection into ...
Kenji M. Fujihara +11 more
semanticscholar +1 more source
F1000Research, 2023 Background: The objective of this study was to estimate the prevalence of adolescent pregnancy among sexually active adolescents, and identify the factors associated with this problem.
Carlos S. Mamani-García +7 more
doaj +1 more source
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death
EMBO Molecular Medicine, 2020 The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR‐246 (PRIMA‐1Met/Eprenetapopt) is converted to methylene quinuclidinone (MQ) that targets mutant p53 protein and perturbs cellular antioxidant balance.
S. Ceder +15 more
semanticscholar +1 more source
Geometric functionals of fractal percolation
, 2020 Fractal percolation exhibits a dramatic topological phase transition, changing abruptly from a dust-like set to a system spanning cluster. The transition points are unknown and difficult to estimate.
Klatt, Michael A., Winter, Steffen
core +1 more source
First passage problems for upwards skip-free random walks via the $\Phi,W,Z$ paradigm [PDF]
, 2018 We develop the theory of the $W$ and $Z$ scale functions for right-continuous (upwards skip-free) discrete-time discrete-space random walks, along the lines of the analogue theory for spectrally negative L\'evy processes.
Avram, Florin, Vidmar, Matija
core +4 more sources
Haematologica, 2020 Mutations of the tumor suppressor gene TP53 represent a common mutation in myeloid malignancies, occurring in 10-20% of patients with de novo myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) with profound negative impact on outcomes and a
D. Sallman
semanticscholar +1 more source
Blood, 2019 Introduction: TP53 gene mutations (mTP53), found in up to 20% of MDS or AML pts and 30-40% of therapy-related (TR) MDS/AML cases, represent a distinct molecular cohort with poor outcomes.
D. Sallman +23 more
semanticscholar +1 more source