Results 291 to 300 of about 114,443 (322)

Topical aprotinin in cardiac operations

The Annals of Thoracic Surgery, 1994
We performed a prospective, randomized, double-blind trial of topical aprotinin versus placebo in 100 patients undergoing cardiac operations with cardiopulmonary bypass. Fifty-five patients received aprotinin. Forty underwent coronary artery bypass grafting (CABG) and 15 valve replacement +/- CABG.
Nick Giannopoulos, Alberto Forni, Neeraj Mediratta, David J. O'Regan, Simon W.H. Kendall, Stephen Westaby, Ravi Pillai   +6 more
openaire   +3 more sources

Aprotinin® diminishes inflammatory processes

International Journal of Cardiology, 1996
Many of the recent reports concerning cytokine levels in cardiopulmonary bypass have documented changes in the levels of these trauma indicators. In the present report, we also document their levels but in the presence of Aprotinin. Aprotinin is a protease inhibitor used not only to diminish bleeding, but also to diminish elements of the diffuse ...
Alan R. Hartman, Rasjid Soeparwata, Hans H. Scheld, Uwe Frerichmann, George B. Stefano, Thomas V. Bilfinger   +5 more
openaire   +3 more sources

A comparison of the effect of aprotinin and ε-aminocaproic acid on renal function in children undergoing cardiac surgery.

Journal of Cardiothoracic and Vascular Anesthesia, 2011
OBJECTIVE To assess the incidence of renal injury among pediatric patients who received aprotinin while undergoing cardiac surgery compared with those who received ε-aminocaproic acid (EACA). DESIGN A retrospective observational study.
Galina Leyvi, Olivia Nelson, Adam Yedlin, Michelle Pasamba, P. Belamarich, Singh Nair, H. Cohen   +6 more
semanticscholar   +1 more source

Antiinflammatory Effects of Aprotinin

Transfusion Alternatives in Transfusion Medicine, 2004
SUMMARYAprotinin is a serine protease inhibitor that binds to human serine proteases with various affinities. This small protein has profound effects on the systemic inflammatory response syndrome induced by cardiopulmonary bypass. The intersecting pathways of complement, cytokines, coagulation, fibrinolytic, and kinin‐kallikrein systems all converge ...
openaire   +2 more sources

Managing Fibrinolysis Without Aprotinin

The Annals of Thoracic Surgery, 2010
Cardiopulmonary bypass increases perioperative bleeding and produces a consumptive coagulopathy, which is defined as the simultaneous production of thrombin and fibrinolysis. Thrombin formation and fibrinolysis primarily occur in the surgical wound and peak at the time heparin is reversed by protamine.
openaire   +3 more sources

Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery: A multicentre observational study

European Journal of Anaesthesiology, 2017
Elsa Deloge, J. Amour, S. Provenchère, B. Rozec, B. Scherrer, A. Ouattara   +5 more
semanticscholar   +1 more source

The current place of aprotinin in the management of bleeding

Anaesthesia, 2015
D. Royston
semanticscholar   +1 more source

Aprotinin revisited: formulation, characterization, biodistribution and therapeutic potential of new aprotinin microemulsion in acute pancreatitis

Journal of drug targeting (Print), 2015
H. Karasulu, N. Oruç, Neslihan Üstündağ-Okur, Derya İlem Özdemir, Zeynep Ay Şenyiğit, Funda Barbet Yılmaz, M. Aşıkoğlu, H. Özkılıç, E. Akçiçek, T. Güneri, Ö. Özütemiz   +10 more
semanticscholar   +1 more source

Aprotinin

International Anesthesiology Clinics, 2004
openaire   +2 more sources

No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin

Liver transplantation, 2014
N. Schofield, A. Sugavanam, K. Thompson, S. Mallett   +3 more
semanticscholar   +1 more source