Results 141 to 150 of about 329 (162)

Systematic AQbD-Driven Formulation of Clarithromycin SNEDDS for Enhanced Biopharmaceutical Performance

International Journal of Drug Delivery Technology
The therapeutic efficacy of clarithromycin, a BCS Class II medication, is limited by its poor water solubility, acid instability, and variable oral bioavailability. Analytical Quality by Design (AQbD) was used to build a SelfNanoemulsifying Drug Delivery System (SNEDDS) in order to get around these restrictions. To choose an appropriate oil, surfactant,
Vivek U. Powar, Rajanikant B. Ghotane, Prathmesh R. Demanna, Rushikesh V. Kadam, Shreeyash D. Kotmire   +4 more
openaire   +1 more source

Analytical Quality by Design (AQbD): A Comprehensive Review with Emphasis on Risk Assessment Approaches

International Journal of Research in Pharmacy and Allied Science
Analytical Quality by Design (AQbD) is an innovative framework that enhances the robustness, reliability, and regulatory compliance of analytical methods through a systematic, science- and risk-based approach. This review article provides a comprehensive overview of the AQbD paradigm, with a particular emphasis on the integration and application of ...
Palak Jethava, Dr. Nilesh Patel
openaire   +1 more source

Stability-Indicating RP-HPLC Method for Determination of Empagliflozin using AQbD Approach

International Journal of Research in Pharmacy and Allied Science
Empagliflozin is a selective sodium–glucose co-transporter-2 (SGLT2) inhibitor used in the treatment of type 2 diabetes mellitus. The present study focuses on the development and optimization of a stability-indicating RP-HPLC method using an Analytical Quality by Design (AQbD) approach.
Shital Chaudhari, Dr. Vishwas Bhagat, Dr. R V. Shete   +2 more
openaire   +1 more source

Comprehensive review on Alfuzosin quantification: Analytical techniques and the evolution of AQbD in method development

International Journal of Research in Pharmacy and Allied Science
Alfuzosin is an alpha-adrenergic antagonist that is used in the treatment of benign prostatic hyperplasia. With a focus on spectroscopic and chromatographic techniques, this review critically examines the many analytical procedures developed for alfuzosin evaluation.
Patlolla Pravalika, Jaggayagari Sarika, Panuganti Pranavi, Kondam Rithikesh, Tadikonda Rama Rao   +4 more
openaire   +1 more source

Development of UHPLC method for the analysis of pimavanserin and its impurities using AQbD principles

2020
Traditional approach to method development based on varying one-factor-at-a-time (OFAT), especially from the industry point of view, is time-consuming and therefore extremely expensive process. In recent years, development of analytical methods is based on the principles of analytical quality by design (AQbD) as a part of a full risk assessment ...
Radić, Irena, Lasić, Zlata, Runje, Mislav, Babić, Sandra   +3 more
openaire   +1 more source

Analytical quality-by-design (AQbD) guided development of a robust HPLC method for the quantification of plumbagin from Plumbago species

Journal of Liquid Chromatography and Related Technologies, 2021
, Pavitra Solanki, V Sundaresan
exaly  

Development and optimization of a LC-MS/MS compatible method for quantification of losartan, hydrochlorothiazide and their impurities using AQbD approach and measurement uncertainty evaluation

Talanta, 2023
Felipe Rebello Lourenço
exaly  

Method Development Based on an Analytical Quality by Design (AQBD) Approach

Tese de Doutoramento em Ciências Farmacêuticas apresentada à Faculdade de ...
openaire   +1 more source

Fractional factorial and central composite design for implementation of risk and DoE-based enhanced AQbD approach to eco-friendly HPTLC method for estimation of dalfampridine in pharmaceutical dosage forms and human plasma

Journal of the Iranian Chemical Society, 2021
Shailesh Shāh, Pintu Prajapati, Shāh Shailesh A   +2 more
exaly  

DoE‐assisted development and validation of a stability‐indicating HPLC‐DAD method for simultaneous determination of five cannabinoids in Cannabis sativa L. based on analytical quality by design (AQbD) concept

Phytochemical Analysis, 2022
Maira Ribeiro De Souza, Amelia Henriques, Renata Limberger   +2 more
exaly