Results 151 to 160 of about 292,069 (296)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Structural basis for substrate-dependent allostery in oxygen activation by a cytochrome P450 enzyme revealed by analysis at different temperatures. [PDF]

Chem Sci
Podgorski MN, McDougal DP, Campbell EC, Bruning JB, Bell SG.   +4 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

3D printed system using <i>ex vivo</i> porcine eye globes to investigate intracorneal absorption of dexpanthenol from contact lens care solution and eye drops. [PDF]

Int J Pharm X
Santer V, El Guamra AM, Kawaguchi T, Lamrani M, Kalia YN.   +4 more
europepmc   +1 more source

Measuring Consumer Aversion Toward AI in Marketing Communication and Assessing Its Relationship to Brand Perceptions and Purchase Intention

Journal of Consumer Behaviour, EarlyView.
ABSTRACT Some consumers exhibit aversion toward artificial intelligence (AI), particularly when it is embedded in persuasive marketing communication (MarCom). Here, we developed and validated a measure of consumer aversion to AI in MarCom and examined its downstream consequences for brand perceptions and purchase intention.
Louvins Pierre, Viviana Carolina Zambrano Rodriguez, Jiayi (Joy) Wang   +2 more
wiley   +1 more source

The Impact of Advanced Surface Moisturizing Technologies on Contact Lens Comfort in Digital Platform Users. [PDF]

Turk J Ophthalmol
Arslantürk Eren M, Büyüktepe TÇ, Uçakhan-Gündüz ÖÖ.   +2 more
europepmc   +1 more source

Morphological Control of Aurophilic Chains of Gold(I) Dithiolate Dimers With Alkali and Alkali Earth Cations

Chemistry – A European Journal, EarlyView.
Luminescent coordination polymers of Group 1 (Li, K, Cs) and 2 (Mg─Ba) cations with gold(I) iso‐maleonitriledithiolate ({Au2[S2C = C(CN)2]}2−) units were prepared; 1‐D aurophilic chains are present in all cases. The structures strongly depend on cation charge and size, with N‐cyano coordination observed in the Gp 1 and larger Gp 2 cations. Increasingly
Jefferson A. Pells, William W. L. Ho, Daniel B. Leznoff   +2 more
wiley   +1 more source

Using an external evaluation to inform the ongoing development of AQuA’s Integrated Care Programme in North West England

International Journal of Integrated Care, 2014
Nicki McNaney, Elizabeth Bradbury
doaj   +3 more sources

Photocatalytic Vanadium‐Mediated Amination of Benzene With Hydroxylamine

Chemistry – A European Journal, EarlyView.
Photochemical activation of N‐phenylphenothiazine (PPT) enables a selective direct benzene amination with hydroxylamine in the presence of various vanadium catalysts under mild reaction conditions. Spectroscopic and kinetic analyses identify a key vanadium(IV)‐hydroxylamine intermediate, elucidate the crucial roles of the acidic medium, the ...
Dana Králová, Maximilian Philipp, Matthias Schmalzbauer, Thilo Reiter, Bernd Schäfer, Ruth M. Gschwind, Burkhard König   +6 more
wiley   +1 more source

Developing change management tools to support AQuA’s Integrated Care Programme in North West England

International Journal of Integrated Care, 2014
Nicki McNaney, Elizabeth Bradbury
doaj   +3 more sources