Results 91 to 100 of about 57,369 (303)
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Frontiers in Pharmacology, 2014 Classically, aquaporins are divided based on pore selectivity into water specific, orthodox aquaporins and solute-facilitating aquaglyceroporins, which conduct e.g. glycerol and urea.
Janis eRambow +3 more
doaj +1 more source
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Advanced Science, EarlyView.By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen +11 more
wiley +1 more source
Cells, 2019 Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the
Laura V. Ellis +4 more
doaj +1 more source
Aquaporin-Incorporated Biomimetic Membranes
, 2016 Aquaporin, a transmembrane protein, has attracted attention globally since its serendipitous discovery by Peter Agre in 1992 (Agre 2006). Its facilitation in rapid and selective water transport has inspired many scientists to utilize this unique function
Guofei Sun +9 more
core +1 more source
, 2022 BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914) +25 more
core +1 more source
Advanced Science, EarlyView.Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han +11 more
wiley +1 more source
, 2022 BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914) +25 more
core +1 more source
Toward Rational Design of Aqueous Battery Membranes Beyond the Selectivity‐Conductivity Trade‐Off
Advanced Science, EarlyView.This review examines sulfonated membranes for redox flow batteries. It focuses on proton transport mechanism, membrane design, performance limits, optimization strategies, and the pathway from molecular design to membrane manufacturing. ABSTRACT Electrochemical energy‐storage systems increasingly require membranes that can simultaneously deliver fast ...
Jinkang Liu +13 more
wiley +1 more source
Frontiers in Pharmacology, 2015 Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
Jane Claire Munday +3 more
doaj +1 more source