Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators [PDF]
Marine DrugsAquaporins (AQPs) are a family of integral membrane proteins that selectively transport water and glycerol across the cell membrane. Because AQPs are involved in a wide range of physiological functions and pathophysiological conditions, AQP-based ...
Ji Woo Im +6 more
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Structural insights into drug transport by an aquaglyceroporin [PDF]
Nature CommunicationsPentamidine and melarsoprol are primary drugs used to treat the lethal human sleeping sickness caused by the parasite Trypanosoma brucei. Cross-resistance to these two drugs has recently been linked to aquaglyceroporin 2 of the trypanosome (TbAQP2 ...
Wanbiao Chen +10 more
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Aquaglyceroporins in Human Breast Cancer [PDF]
Cells, 2023 Aquaporins are water channels that facilitate passive water transport across cellular membranes following an osmotic gradient and are essential in the regulation of body water homeostasis.
Teresa Kirkegaard +3 more
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Effects of Transporter Inhibitors and Chemical Analogs on the Uptake of Antimonite and Antimonate by Boehmeria nivea L. [PDF]
Toxics, 2023 Antimony (Sb) is a non-essential metalloid that can be taken up by plants from contaminated soils and thus enter the food chain and threaten human health. Boehmeria nivea L. (ramie) is a promising phytoremediation plant for Sb-polluted soils.
Yi Lu +4 more
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Computing the Dissociation Constant from Molecular Dynamics Simulations with Corrections for the Large Pressure Fluctuations—Aquaglyceroporins Have High Affinity for Their Substrate Glycerol [PDF]
BiomoleculesIn this paper, we consider the inevitable large fluctuations of pressure in typical molecular dynamics (MD) simulations of ligand–protein binding problems.
Md Mohsin, Hans R. Loja, Liao Y. Chen
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Comparative Functional Analysis Reveals Conserved Roles of Aquaporins Under Osmotic Dehydration in Steinernema carpocapsae Strains [PDF]
BiologyEntomopathogenic nematodes (EPNs), including Steinernema and Heterorhabditis, are obligate insect parasites widely used in biological pest control. However, their efficacy is often limited by susceptibility to environmental stresses like desiccation ...
Yongqi Chen, Qiuyue Huang, Xun Yan
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Application of the Transition State Theory in the Study of the Osmotic Permeabilities of AQP7, AQP10 and GlpF [PDF]
MembranesAquaglyceroporins, including human AQP7, AQP10, and E. coli GlpF, are known to facilitate movements of glycerol, water, and some other uncharged molecules across the cell membrane.
Ruth Chan, Liao Y. Chen
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Physiological ReportsThe aquaporin genes (aqps) are widely distributed among vertebrates. In cartilaginous fish, aqp3 and aqp10 are duplicated, whereas many species have lost aqp8.
Shinichiro Hidaka +2 more
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Glycosomal Aquaglyceroporin 1 dual role in iron homeostasis and antimony susceptibility in Leishmania amazonensis. [PDF]
PLoS Neglected Tropical DiseasesLeishmania parasites cause a spectrum of diseases known as leishmaniases and must acquire nutrients like iron while surviving host defenses. Aquaglyceroporin 1 (AQP1) is a membrane channel that, in L.
Romario Lopes Boy +5 more
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Biomolecules, 2023 More than 20 years have passed since the first demonstration of Aquaporin-9 (AQP9) in the brain. Yet its precise localization and function in brain tissue remain unresolved.
Soulmaz Zahl +7 more
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