Results 21 to 30 of about 1,538 (126)
Molecular Basis of Aquaporin-7 Permeability Regulation by pH
Cells, 2018 The aquaglyceroporin AQP7, a family member of aquaporin membrane channels, facilitates the permeation of water and glycerol through cell membranes and is crucial for body lipid and energy homeostasis.
Andreia F. Mósca +9 more
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FEBS Open Bio, 2015 Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causesnephrogenic diabetes insipidus in ...
Noreen Klein +3 more
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Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress
eLife, 2015 In eukaryotes, exposure to hypertonic conditions activates a MAPK (Hog1 in Saccharomyces cerevisiae and ortholog p38 in human cells). In yeast, intracellular glycerol accumulates to counterbalance the high external osmolarity. To prevent glycerol efflux,
Alexander Muir +4 more
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Scientific Reports, 2021 The inability to over-express Aquaporin 6 (AQP6) in the plasma membrane of heterologous cells has hampered efforts to further characterize the function of this aquaglyceroporin membrane protein at atomic detail using crystallographic approaches. Using an
D. C. Soler +7 more
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Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. [PDF]
PLoS ONE, 2018 More than 90% of the cases of Parkinson's disease have unknown etiology. Gradual loss of dopaminergic neurons of substantia nigra is the main cause of morbidity in this disease. External factors such as environmental toxins are believed to play a role in
Katja Stahl +12 more
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Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. [PDF]
PLoS ONE, 2013 BACKGROUND: Glycerol outflow from adipocytes has been considered for a decade to be mediated by aquaporin-7, an aquaglyceroporin highly expressed in the adipose tissue. Its involvement in glycerol metabolism has been widely studied also in humans. Recent
Umberto Laforenza +2 more
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Cells, 2021 Aquaporins are required by cells to enable fast adaptation to volume and osmotic changes, as well as microenvironmental metabolic stimuli. Aquaglyceroporins play a crucial role in supplying cancer cells with glycerol for metabolic needs.
Andreia de Almeida +5 more
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Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence. [PDF]
Interdiscip Perspect Infect DisTrypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Amisigo CM +13 more
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Frontiers in Pharmacology, 2014 Classically, aquaporins are divided based on pore selectivity into water specific, orthodox aquaporins and solute-facilitating aquaglyceroporins, which conduct e.g. glycerol and urea.
Janis eRambow +3 more
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Characterization of Leishmania donovani aquaporins shows presence of subcellular aquaporins similar to tonoplast intrinsic proteins of plants. [PDF]
PLoS ONE, 2011 Leishmania donovani, a protozoan parasite, resides in the macrophages of the mammalian host. The aquaporin family of proteins form important components of the parasite-host interface.
Neha Biyani +6 more
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