Results 21 to 30 of about 1,989 (206)
The Mechanism of Glycerol Conduction in Aquaglyceroporins [PDF]
Structure, 2001 The E. coli glycerol facilitator, GlpF, selectively conducts glycerol and water, excluding ions and charged solutes. The detailed mechanism of the glycerol conduction and its relationship to the characteristic secondary structure of aquaporins and to the NPA motifs in the center of the channel are unknown.Molecular dynamics simulations of GlpF reveal ...
Jensen, Morten Ø. +2 more
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Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap
Life, 2022 (1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was ...
Katharina Geistlinger +2 more
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Aquaglyceroporins: Generalized metalloid channels [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Aquaporins (AQPs), members of a superfamily of transmembrane channel proteins, are ubiquitous in all domains of life. They fall into a number of branches that can be functionally categorized into two major sub-groups: i) orthodox aquaporins, which are water-specific channels, and ii) aquaglyceroporins, which allow the transport of water, non-polar ...
Rita, Mukhopadhyay +2 more
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Frontiers in Marine Science, 2022 Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water and small solutes across cell membranes. These proteins are vital for maintaining water homeostasis in living organisms.
Zhongkai Wang +8 more
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Arsenic transport by zebrafish aquaglyceroporins [PDF]
BMC Molecular Biology, 2009 Abstract Background Arsenic is one of the most ubiquitous toxins and endangers the health of tens of millions of humans worldwide. It is a mainly a water-borne contaminant. Inorganic trivalent arsenic (AsIII) is one of the major species that exists environmentally.
Hamdi, Mohamad +6 more
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Mechanism of selectivity in aquaporins and aquaglyceroporins [PDF]
Proceedings of the National Academy of Sciences, 2008 Aquaporins and aquaglyceroporins form a family of pore proteins that facilitate the efficient and selective flux of small solutes across biological membranes. We studied the selectivity of aquaporin-1 (AQP1) and the bacterial glycerol facilitator, GlpF, for O 2 , CO 2
Hub, J., de Groot, B.
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Frontiers in Physics, 2020 In this article, the Brownian dynamics fluctuation-dissipation theorem (BD-FDT) is applied to the study of transport of neutral solutes across the cellular membrane of Plasmodium berghei (Pb), a disease-causing parasite.
Liao Y. Chen
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Boric acid transport activity of human aquaporins expressed in Xenopus oocytes
Physiological Reports, 2022 Boric acid is a vital micronutrient that is toxic at high concentrations in animals. However, the mechanisms underlying boric acid transport in animal cells remain unclear.
Kazutaka Ushio +8 more
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Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes [PDF]
International Journal of Molecular Sciences, 2020 Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form. However, the biological pathways involved in the browning process are still unclear.
Inês Vieira da Silva +5 more
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Aquaglyceroporins and orthodox aquaporins in human adipocytes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2022 Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells.
Peng, Huang +7 more
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