Results 41 to 50 of about 1,538 (126)

Potentially Toxic Elements and Male Reproductive Toxicity: Mechanisms, Implications, and Protective Strategies: A Narrative Review

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Potentially toxic elements impair male reproductive function through oxidative stress, DNA damage, mitochondrial dysfunction, inflammation, endocrine disruption and epigenetic alterations. Antioxidants, phytochemicals, chelating agents and healthy lifestyle interventions may help mitigate testicular toxicity and preserve fertility.
Sakshi Yadav, Placheril J John
wiley   +1 more source

Gold(III) Pyridine-Benzimidazole Complexes as Aquaglyceroporin Inhibitors and Antiproliferative Agents

Inorganics, 2018
Gold compounds have been proven to be novel and versatile tools for biological applications, including as anticancer agents. Recently, we explored the potential of Au(III) complexes with bi-dentate N-donor ligands as inhibitors of the membrane water and ...
Brech Aikman, Margot N. Wenzel, Andreia F. Mósca, Andreia de Almeida, Wim T. Klooster, Simon J. Coles, Graça Soveral, Angela Casini   +7 more
doaj   +1 more source

Orchid genome evolution and trait innovation

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2577-2607, August 2026.
Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng, Cheng‐Yuan Zhou, Linying Wang, Jie Gao, Weilun Yin, Dong‐Hui Peng, Siren Lan, Feng‐Xi Yang, Zhong‐Jian Liu   +8 more
wiley   +1 more source

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant ...
Fabrice E. Graf, Nicola Baker, Jane C. Munday, Harry P. de Koning, David Horn, Pascal Mäser   +5 more
doaj   +1 more source

Mind the Porins: Differential Effects of Porin Knockouts and Overexpression on Glucose and Xylose Uptake and Utilization in Pseudomonas putida

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
Altering the levels of outer membrane (OM) porins has an effect on the dynamics of the utilization and co‐utilization of native (glucose—green hexagon) and non‐native (xylose—brown pentagon) sugars, as well as the accumulation of their oxidation byproducts in Pseudomonas putida cultures.
Barbora Popelářová, Nicolas T. Wirth, Daniel C. Volke, Tibor Botka, Pablo I. Nikel, Pavel Dvořák   +5 more
wiley   +1 more source

Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs

BMC Cancer, 2012
Background Nucleoside analogs used in the chemotherapy of solid tumors, such as the capecitabine catabolite 5′-deoxy-5-fluorouridine (5′-DFUR) trigger a transcriptomic response that involves the aquaglyceroporin aquaporin 3 along with other p53-dependent
Trigueros-Motos Laia, Pérez-Torras Sandra, Casado F, Molina-Arcas Míriam, Pastor-Anglada Marçal   +4 more
doaj   +1 more source

Reviving the Skin From Within: Mechanistic Insights Into a Well‐Tolerated Dermal Filler—CPM‐HA20G

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Dermal fillers composed of hyaluronic acid (HA) combined with glycerol have been clinically shown to enhance skin hydration and quality; the precise mechanisms underlying their efficacy have yet to be fully elucidated. Aims Investigation of the dual hydration mechanisms, cell protection and tolerability, and tissue compatibility of ...
Kay Marquardt, Christian Hartmann, Sonja Sattler, Je‐Young Park, Ting Song Lim, Luis Alberto Parra Hernandez, Christina Wollenburg, Daniela Schäfer, Sarah Hetier‐Jaccoud, Thomas Hengl   +9 more
wiley   +1 more source

Phosphate Transporters Mediate the Uptake of Monothioarsenate

Plant, Cell &Environment, Volume 49, Issue 5, Page 2628-2638, May 2026.
ABSTRACT Arsenic (As) is one of the most problematic environmental toxins. Exposure to As, predominantly via drinking water and the intake of food, represents a major human health threat. Various species of As exist in the environment, among them organic and inorganic thioarsenates.
Sebastian Haider, Sylvia Hafner, Britta Planer‐Friedrich, Stephan Clemens   +3 more
wiley   +1 more source

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.

PLoS Pathogens, 2017
Aquaglyceroporins (AQPs) transport water and glycerol and play important roles in drug-uptake in pathogenic trypanosomatids. For example, AQP2 in the human-infectious African trypanosome, Trypanosoma brucei gambiense, is responsible for melarsoprol and ...
Laura Jeacock, Nicola Baker, Natalie Wiedemar, Pascal Mäser, David Horn   +4 more
doaj   +1 more source

Identification and expression analysis of aquaporins in the potato psyllid, Bactericera cockerelli. [PDF]

PLoS ONE, 2014
Aquaporin (AQPs) proteins transport water and uncharged low molecular-weight solutes across biological membranes. Six to 8 AQP genes have been identified in many insect species, but presently only three aquaporins have been characterized in phloem ...
Freddy Ibanez, Joseph Hancock, Cecilia Tamborindeguy   +2 more
doaj   +1 more source