Results 1 to 10 of about 4,789 (161)

Genome‐wide identification and solute selectivity of aquaporins in the sharpnose sevengill shark, Heptranchias perlo [PDF]

Physiological Reports
The aquaporin genes (aqps) are widely distributed among vertebrates. In cartilaginous fish, aqp3 and aqp10 are duplicated, whereas many species have lost aqp8.
Shinichiro Hidaka, Ayumi Nagashima, Akira Kato   +2 more
doaj   +3 more sources

Salivary AQP9 mRNA expression is associated with caries and periodontitis prevalence [PDF]

Scientific Reports
Dental caries and periodontitis are the most frequently diagnosed dental diseases worldwide. Their occurrence is age-dependent and, due to their widespread prevalence, they represent a major public health challenge.
Markus Baumann, Katharina Rump, Dominik Ziehe, Bjoern Koos, Michael Adamzik, Jennifer Orlowski, Martin Kunkel, Daria Pakosch-Nowak   +7 more
doaj   +5 more sources

Selective Blockade of Two Aquaporin Channels, AQP3 and AQP9, Impairs Human Leukocyte Migration [PDF]

Cells
Peripheral blood leukocytes are able to migrate to the inflamed tissue, and to engulf and kill invading microbes. This requires rapid modifications of cell morphology and volume through fast movements of osmotic water into or out of the cell.
Sabino Garra, Charlotte Mejlstrup Hymøller, Daria Di Molfetta, Nicola Zagaria, Patrizia Gena, Rosa Angela Cardone, Michael Rützler, Svend Birkelund, Giuseppe Calamita   +8 more
doaj   +5 more sources

AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression

Biochemistry and Biophysics Reports, 2022
Macrophages play a major role in the immune defense against pathogenic factors; however, they can lead to tumor exacerbation and metastasis, as the tumor microenvironment (TME) polarizes tumor-associated macrophages (TAMs) into the M2 subtype. Lactate, a
Yundi Shi, Masato Yasui, Mariko Hara-Chikuma   +2 more
exaly   +3 more sources

AQP9 Is a Prognostic Factor for Kidney Cancer and a Promising Indicator for M2 TAM Polarization and CD8+ T-Cell Recruitment

Frontiers in Oncology, 2021
BackgroundIt is undeniable that the tumor microenvironment (TME) plays an indispensable role in the progression of kidney renal clear cell carcinoma (KIRC). However, the precise mechanism of activities in TME is still unclear.Methods and ResultsUsing the
Nieke Zhang, Chen Saisai, Liu Chunhui
exaly   +3 more sources

Aquaporin 9 downregulation in KRASG12V colorectal cancer and associated with increased proliferation and decreased apoptosis in cancer cells [PDF]

Scientific Reports
Patients with colorectal cancer (CRC) carrying KRAS mutations face a challenging prognosis, especially due to their reduced response to EGFR inhibitor therapies.
Yankui Liu, Jiahao Dou, Qi Tan, Shuning Chen, Yaru Li, Rong Wang, Ning Sun, Xiaowei Qi   +7 more
doaj   +2 more sources

Maternal Protein Restriction Modulates Angiogenesis and AQP9 Expression Leading to a Delay in Postnatal Epididymal Development in Rat

Cells, 2019
The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions.
Marilia Cavariani, Chuffa Lg, Bruno Cesar Schimming   +2 more
exaly   +3 more sources

Population Genomics Provides Novel Insights Into Evolutionary Relationships and Local Adaptation of Two Ecotypes <i>Coilia nasus</i>. [PDF]

Ecol Evol
Based on whole‐genome resequencing, we determined that the freshwater‐resident form (C. nasus taihuensis) is an ecotype of anadromous Coilia nasus, not a distinct subspecies. The two ecotypes diverged approximately 4.6 thousand years ago, coinciding with the formation of Tai Lake.
Ma F, Wang S, Ma W, Wang H, Jin H, Peng L, Yin G, Liu K.   +7 more
europepmc   +2 more sources

Targeting AQP9 enhanced the anti-TNF therapy response in Crohn's disease by inhibiting LPA-hippo pathway

Pharmacological Research
Although anti-TNF antibodies are extensively used to treat Crohn's disease (CD), a significant proportion of patients, up to 40%, exhibit an inadequate response to this therapy.
Minhao Yu, Yuan Shi, Yuan Gao, Yang Luo, Yihua Jin, Xiaoyi Liang, Zhuoran Tao, Guojun Zhu, Haiping Lin, Hao Li, Jun Qin, Zhijun Cao, Ming Zhong   +12 more
exaly   +3 more sources

Identification and validation of palmitoylation-related biomarkers in gestational diabetes mellitus [PDF]

Scientific Reports
Palmitoylation plays a crucial role in the pathophysiology of diabetes, and an increase in palmitoylation may inhibit the function of insulin receptors, thereby affecting the progression of gestational diabetes mellitus (GDM). However, its involvement in
Kai Zhang, Xiaoyang Shi, Rongrong Bian, Wei Shi, Li Yang, Chenchen Ren   +5 more
doaj   +2 more sources