Results 41 to 50 of about 4,789 (161)
Journal of Nanobiotechnology, 2021 Background Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that transferrin-functionalised porous silicon nanoparticles (Tf@pSiNPs) can inhibit the ...
Youssef Abdalla +5 more
doaj +1 more source
The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker
Biomolecules, 2022 Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis ...
Inês V. da Silva +3 more
doaj +1 more source
Molecular Carcinogenesis, EarlyView.ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham +8 more
wiley +1 more source
Cancer Cell International, 2022 Background Arsenic trioxide (ATO) is highly effective in acute promyelocytic leukemia (APL) patients, but it fails to show satisfactory efficacy in other acute myeloid leukemia (AML) patients with non-APL subtypes.
Wanbin Fu +9 more
doaj +1 more source
Aquaglyceroporins in Human Breast Cancer
Cells, 2023 Aquaporins are water channels that facilitate passive water transport across cellular membranes following an osmotic gradient and are essential in the regulation of body water homeostasis.
Teresa Kirkegaard +3 more
doaj +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Near‐infrared non‐ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence‐dependent continuum of tissue modulation, based on evidence from 27 studies of lasers ...
Guy Erlich +4 more
wiley +1 more source
Effect of AQP9 Expression in Androgen-Independent Prostate Cancer Cell PC3 [PDF]
International Journal of Molecular Sciences, 2016 It is known that aquaporin 9 (AQP9) in the prostate was strictly upregulated by androgen and may represent a novel therapeutic target for several cancers, but whether AQP9 plays a role in the regulation of androgen-independent prostate cancer still remains unclear. In the present study, AQP9 was determined in prostate cancer and adjacent cancer tissues;
Chen, Qiwei +8 more
openaire +2 more sources
Prognostic implications of Aquaporin 9 expression in clear cell renal cell carcinoma
Journal of Translational Medicine, 2019 Background Growing evidence has demonstrated immune reactivity as a confirmed important carcinogenesis and therapy efficacy for clear cell renal cell carcinoma (ccRCC).
Wen-Hao Xu +9 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site [PDF]
Molecular Membrane Biology, 2013 The involvement of aquaporin (AQP) water and small solute channels in the etiology of several diseases, including cancer, neuromyelitis optica and body fluid imbalance disorders, has been suggested previously. Furthermore, results obtained in a mouse model suggested that AQP9 function contributes to hyperglycemia in type-2 diabetes.
Wacker, SJ +5 more
openaire +5 more sources