Results 51 to 60 of about 4,789 (161)

An Atypical Aquaporin 1 Derived From Paramecium multimicronucleatum Functions as a Multifunctional Channel That Permeates Water, Glycerol, and Urea

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Although it had been reported that the translation product of the functional aquaporin gene, aqp1, is localized to the contractile vacuole complex of Paramecium multimicronucleatum, the molecules that pass through this channel protein had not been identified. In the present study, we introduced and expressed this protein in Xenopus oocytes and
Masaki Ishida, Shuichi Ueno, Takashi Tominaga, Kurumi Tanaka, Akito Horikawa, Manabu Hori   +5 more
wiley   +1 more source

The association of transporter genes polymorphisms and lung cancer chemotherapy response. [PDF]

PLoS ONE, 2014
Lung cancer is one of the most common cancers and is the leading cause of death worldwide. Platinum-based chemotherapy is the main treatment method in lung cancer patients.
Ying Wang, Ji-Ye Yin, Xiang-Ping Li, Juan Chen, Chen-Yue Qian, Yi Zheng, Yi-Lan Fu, Zi-Yu Chen, Hong-Hao Zhou, Zhao-Qian Liu   +9 more
doaj   +1 more source

Characterization and Computational Engineering of Structural Elements Controlling Gas Permeability in PIP2;1 Aquaporins

Journal of Computational Chemistry, Volume 47, Issue 11, 30 April 2026.
Bulky residues constrict the central pore of WT SoPIP2;1, generating high energy barriers for both O2 and CO2 and preventing gas permeation. ABSTRACT Aquaporins (AQPs) are classical water channels that also conduct small gas molecules such as O2$$ {\mathrm{O}}_2 $$ and CO2$$ {\mathrm{CO}}_2 $$ across the membrane.
Ahmad Raeisi Najafi, Paween Mahinthichaichan, Fraser J. Moss, Ardeschir Vahedi‐Faridi, Walter F. Boron, Emad Tajkhorshid   +5 more
wiley   +1 more source

Aquaporin-9 Contributes to the Maturation Process and Inflammatory Cytokine Secretion of Murine Dendritic Cells

Frontiers in Immunology, 2018
Dendritic cells (DCs) are the most potent antigen-presenting cells able to trigger the adaptive immune response to specific antigens. When non-self-antigens are captured, DCs switch from an “immature” to a “mature” state to fulfill their function.
Stefania De Santis, Stefania De Santis, Stefania De Santis, Grazia Serino, Maria R. Fiorentino, Vanessa Galleggiante, Patrizia Gena, Giulio Verna, Marina Liso, Monica Massaro, Jinggang Lan, Jacopo Troisi, Jacopo Troisi, Ilaria Cataldo, Alessia Bertamino, Aldo Pinto, Pietro Campiglia, Pietro Campiglia, Angelo Santino, Gianluigi Giannelli, Alessio Fasano, Alessio Fasano, Giuseppe Calamita, Marcello Chieppa, Marcello Chieppa   +24 more
doaj   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Metabolic Alterations in Macrophage Subtypes Propel Immune and Stromal Remodeling in Neurofibroma's Malignant Progression

MedComm, Volume 7, Issue 4, April 2026.
Illustration of the microenvironment factors driving malignant progression in MPNSTs. ABSTRACT Neurofibromatosis type 1 (NF1) is characterized by the development of benign plexiform neurofibromas (PNFs). In 10%–15% of patients, these tumors undergo malignant transformation into aggressive malignant peripheral nerve sheath tumors (MPNSTs).
Ling‐Ling Ge, Yue‐Hua Li, Xuan Yu, Ming‐Yan Xing, Yi‐Hui Gu, Wei Wang, Jing‐Xuan Huang, Jun Liu, Hai‐Bing Zhang, Cheng‐Jiang Wei, Zhi‐Chao Wang, Qing‐Feng Li   +11 more
wiley   +1 more source

RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis

Frontiers in Immunology, 2022
Sepsis is caused by systemic infection and is a major health concern as it is the primary cause of death from infection. It is the leading cause of mortality worldwide and there are no specific effective treatments for sepsis.
Shireen Mohammad, Caroline E. O’Riordan, Chiara Verra, Eleonora Aimaretti, Gustavo Ferreira Alves, Klaus Dreisch, Johan Evenäs, Patrizia Gena, Angela Tesse, Michael Rützler, Michael Rützler, Massimo Collino, Giuseppe Calamita, Christoph Thiemermann   +13 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, Volume 20, Issue 2, Page 260-281, February 2026.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Aquaporin‐1, aquaporin‐3 and aquaporin‐5 differentially modulate cell biophysical and biomechanical properties, impacting cell stiffness and cell–cell adhesion

The FEBS Journal, Volume 293, Issue 3, Page 806-824, February 2026.
GA text Overexpression of aquaporins AQP1, AQP3, or AQP5 in HEK‐293 T cells induced changes in cell biophysical properties and migration. Atomic force microscopy (AFM)–based force spectroscopy studies demonstrated that AQP1 overexpression increased cell stiffness and cell–cell adhesion, AQP3 augmented cell stiffness but reduced cell–cell adhesion ...
Catarina Pimpão, Filomena A. Carvalho, Inês Vieira da Silva, Andreia Barateiro, Nuno C. Santos, Graça Soveral   +5 more
wiley   +1 more source

Metabolic impact of the glycerol channels AQP7 and AQP9 in adipose tissue and liver [PDF]

Journal of Molecular Endocrinology, 2014
Obesity and secondary development of type 2 diabetes (T2D) are major health care problems throughout the developed world. Accumulating evidence suggest that glycerol metabolism contributes to the pathophysiology of obesity and T2D. Glycerol is a small molecule that serves as an important intermediate between carbohydrate and lipid metabolism.
openaire   +4 more sources