Results 71 to 80 of about 4,789 (161)

Immunological and Viral Profiles of Squamous Cell Carcinoma in Transplant and Non‐Transplant Patients in Singapore

JEADV Clinical Practice, Volume 4, Issue 5, Page 1101-1113, December 2025.
Cutaneous squamous cell carcinoma (cSCC) exhibits a pro‐tumorigenic immune environment, increased oncologic signalling, and tumour remodelling, with three immune subgroups from ‘cold’ to ‘hot’. Organ transplant recipients (OTR) with cSCC showed reduced T‐cells and greater viral enrichment, especially HPV, and a higher disease burden.
Choon Chiat Oh, Boon Yee Lim, Elizabeth Chun Yong Lee, Bavani Kannan, Po Yin Tang, Tun Kiat Ko, Clara Wei Teng Koh, Kuan Rong Chan, Jason Yongsheng Chan   +8 more
wiley   +1 more source

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

Environmental Health, 2017
Background Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. Increasing evidence suggests that such sex differences also exist during fetal development.
Emily F. Winterbottom, Devin C. Koestler, Dennis Liang Fei, Eric Wika, Anthony J. Capobianco, Carmen J. Marsit, Margaret R. Karagas, David J. Robbins   +7 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

PLoS Genetics, 2012
Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts with both genome-wide SNP data and serum metabolomic profiles.
Michael Inouye, Samuli Ripatti, Johannes Kettunen, Leo-Pekka Lyytikäinen, Niku Oksala, Pirkka-Pekka Laurila, Antti J Kangas, Pasi Soininen, Markku J Savolainen, Jorma Viikari, Mika Kähönen, Markus Perola, Veikko Salomaa, Olli Raitakari, Terho Lehtimäki, Marja-Riitta Taskinen, Marjo-Riitta Järvelin, Mika Ala-Korpela, Aarno Palotie, Paul I W de Bakker   +19 more
doaj   +1 more source

Biokemijska istraživanja i ekspresija akvaporina 9 (AQP9) u divljih miševa i miševa s odstranjenim genom za AQP9

Veterinarski arhiv, 2010
The objective of this study was to determine the cellular and subcellular localization of AQP9 in different organs of wild-type (AQP9+/+ ) and AQP9 knockout mice (AQP9-/- ) by immunohistochemistry (IHC), immunofl uorescence (IF) and RT-PCR, as well as some biochemical evaluation. Twenty wild and homozygous AQP9 KO-mice (C57 BL/6J) were used. Both AQP9+/
openaire   +2 more sources

Aquaglyceroporins Expression and Glycerol Permeability are modulated by Estradiol in Mouse Sertoli cells

Revista Cubana de Investigaciones Biomédicas, 2020
Introduction: Metabolic diseases are related with severe fertility problems, partly due to increased aromatization of androgens to estrogens. Elevated levels of 17β-Estradiol (E2) are known to cause alterations on normal development of germ cells ...
David F. Carrageta, Raquel L Bernardino, Ana M. Silva, Marco G Alves, Graça Soveral, Pedro F. Oliveira   +5 more
doaj  

From Gene Expression to Candidate Biomarkers in Ulcerative Colitis: Aquaporin-9 in Neutrophil Extracellular Traps Formation Pathways [PDF]

Iranian Journal of Medical Sciences
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). Neutrophil extracellular traps (NETs) have been recognized as contributing to UC progression.
Hawra Zia Hossein Al-Jamali, Farshad Sheikhesmaili, Mohammad Moradad, Amjad Ahmadi, Ali Jalili, Bahram Nikkhoo, Mohammad Reza Rahmani, Shohreh Fakhari   +7 more
doaj   +1 more source

Effects of 3-beta-diol, an androgen metabolite with intrinsic estrogen-like effects, in modulating the aquaporin-9 expression in the rat efferent ductules

Reproductive Biology and Endocrinology, 2006
Background Fluid homeostasis is critical for normal function of the male reproductive tract and aquaporins (AQP) play an important role in maintenance of this water and ion balance.
Hess Rex A, Mahecha Germán AB, Kalapothakis Evanguedes, Reis Adelina M, Oliveira André G, Picciarelli-Lima Patrícia, Oliveira Cleida A   +6 more
doaj   +1 more source

AQP9 and UT‐A facilitate hepatocyte basolateral membrane urea permeability in mouse

The FASEB Journal, 2012
In mammals, nitrogen from protein degradation is disposed as urea. Several studies have investigated expression of urea transporters in hepatocytes, where urea is produced. Nevertheless, the role of protein facilitated urea transport in liver remains unknown.
Sabina Katarzyna Jelen, Patrizia Gena, Janne Lebeck, Jeppe Prætorius, Robert Fenton, Jørgen Frøkiaer, Søren Nielsen, Giuseppe Calamita, Michael Rützler   +8 more
openaire   +1 more source

AQP9 in Neutrophils Promotes the Formation of NETs by Regulating JAK2-STAT3 Pathway-Mediated Pyroptosis to Aggravate Intestinal Epithelial Cell Injury in Ulcerative Colitis

Frontiers in Bioscience-Landmark
Background: Ulcerative colitis (UC) is a chronic inflammatory disorder primarily affecting the rectum and colon. This study aimed to identify potential therapeutic targets that may inhibit UC progression and mitigate patient suffering.
Zetao Wang, Yao Sun, Xiaohui Zhou, Jianing Shi, Lijun Shi   +4 more
doaj   +1 more source