Aquaglyceroporins in Human Breast Cancer [PDF]
Cells, 2023 Aquaporins are water channels that facilitate passive water transport across cellular membranes following an osmotic gradient and are essential in the regulation of body water homeostasis.
Teresa Kirkegaard +3 more
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Genome‐wide identification and solute selectivity of aquaporins in the sharpnose sevengill shark, Heptranchias perlo [PDF]
Physiological ReportsThe aquaporin genes (aqps) are widely distributed among vertebrates. In cartilaginous fish, aqp3 and aqp10 are duplicated, whereas many species have lost aqp8.
Shinichiro Hidaka +2 more
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Narrowed pore conformations of aquaglyceroporins AQP3 and GlpF [PDF]
Nature CommunicationsAquaglyceroporins such as aquaporin−3 (AQP3) and its bacterial homologue GlpF facilitate water and glycerol permeation across lipid bilayers. X-ray crystal structures of GlpF showed open pore conformations, and AQP3 has also been predicted to adopt this ...
Daisuke Kozai +8 more
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Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators [PDF]
Marine DrugsAquaporins (AQPs) are a family of integral membrane proteins that selectively transport water and glycerol across the cell membrane. Because AQPs are involved in a wide range of physiological functions and pathophysiological conditions, AQP-based ...
Ji Woo Im +6 more
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Aquaporin-7-Mediated Glycerol Permeability Is Linked to Human Sperm Motility in Asthenozoospermia and during Sperm Capacitation [PDF]
Cells, 2023 Osmoregulation plays a vital role in sperm function, encompassing spermatogenesis, maturation, and fertilization. Aquaglyceroporins, a subclass of aquaporins (AQPs), facilitate the transport of water and glycerol across the sperm membrane, with glycerol ...
João C. Ribeiro +6 more
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Application of the Transition State Theory in the Study of the Osmotic Permeabilities of AQP7, AQP10 and GlpF [PDF]
MembranesAquaglyceroporins, including human AQP7, AQP10, and E. coli GlpF, are known to facilitate movements of glycerol, water, and some other uncharged molecules across the cell membrane.
Ruth Chan, Liao Y. Chen
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Computing the Dissociation Constant from Molecular Dynamics Simulations with Corrections for the Large Pressure Fluctuations—Aquaglyceroporins Have High Affinity for Their Substrate Glycerol [PDF]
BiomoleculesIn this paper, we consider the inevitable large fluctuations of pressure in typical molecular dynamics (MD) simulations of ligand–protein binding problems.
Md Mohsin, Hans R. Loja, Liao Y. Chen
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Aquaporins in lipid metabolism: functions and regulation in health and disease [PDF]
Lipids in Health and DiseaseAquaporins (AQPs), mainly divided into classical AQPs, aquaglyceroporins, and superaquaporins, constitute a channel protein family facilitating the movement of small molecules, such as H2O, H2O2, and glycerol, across cell membrane.
Yingwei Bi +7 more
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A novel aquaporin Aagp contributes to Streptococcus suis H2O2 efflux and virulence [PDF]
Virulence, 2023 Streptococcus suis is a bacterium that can cause infections in pigs and humans. Although oxidative stress is common occurrence during bacterial growth and infection, the regulation networks of S. suis under oxidative stress remain poorly understood.
Xinchi Zhu +6 more
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Sexual Dimorphism of Adipose and Hepatic Aquaglyceroporins in Health and Metabolic Disorders
Frontiers in Endocrinology, 2015 Gender differences in the relative risk of developing metabolic complications, such as insulin resistance or non-alcoholic fatty liver disease (NAFLD), have been reported.
Angela Tesse +2 more
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