Results 41 to 50 of about 1,373 (155)

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Aquaporins Mediate Silicon Transport in Humans.

PLoS ONE, 2015
In animals, silicon is an abundant and differentially distributed trace element that is believed to play important biological functions. One would thus expect silicon concentrations in body fluids to be regulated by silicon transporters at the surface of
Alexandre P Garneau, Gabriel A Carpentier, Andrée-Anne Marcoux, Rachelle Frenette-Cotton, Charles F Simard, Wilfried Rémus-Borel, Luc Caron, Mariève Jacob-Wagner, Micheline Noël, Jonathan J Powell, Richard Bélanger, François Côté, Paul Isenring   +12 more
doaj   +1 more source

Orchid genome evolution and trait innovation

Journal of Integrative Plant Biology, EarlyView.
Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng, Cheng‐Yuan Zhou, Linying Wang, Jie Gao, Weilun Yin, Dong‐Hui Peng, Siren Lan, Feng‐Xi Yang, Zhong‐Jian Liu   +8 more
wiley   +1 more source

Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs [PDF]

International Journal of Molecular Sciences, 2018
Nuclear receptors, such as the farnesoid X receptor (FXR) and the peroxisome proliferator-activated receptors gamma and alpha (PPAR-γ, -α), are major metabolic regulators in adipose tissue and the liver, where they govern lipid, glucose, and bile acid homeostasis, as well as inflammatory cascades.
Matteo Tardelli, Thierry Claudel, Francesca Virginia Bruschi, Michael Trauner   +3 more
openaire   +2 more sources

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

Aquaglyceroporins but not orthodox aquaporins are involved in the cryotolerance of pig spermatozoa

Journal of Animal Science and Biotechnology, 2019
Background Aquaporins (AQPs) are a family of transmembrane water channels that includes orthodox AQPs, aquaglyceroporins (GLPs) and superAQPs. AQP3, AQP7, AQP9 and AQP11 have been identified in boar sperm, and they are crucial for sperm maturation and ...
Ariadna Delgado-Bermúdez, Marc Llavanera, Leira Fernández-Bastit, Sandra Recuero, Yentel Mateo-Otero, Sergi Bonet, Isabel Barranco, Beatriz Fernández-Fuertes, Marc Yeste   +8 more
doaj   +1 more source

The Ionophores CCCP and Gramicidin but Not Nigericin Inhibit Trypanosoma brucei Aquaglyceroporins at Neutral pH

Cells, 2020
Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei parasites. The T. brucei aquaglyceroporin isoform 2, TbAQP2, has been linked to the uptake of pentamidine.
Lea Madlen Petersen, Eric Beitz
doaj   +1 more source

Arsenic stress in Rice (Oryza sativa) and its amelioration approaches

Plant Stress, 2022
Arsenic (As) contamination is a major environmental issue that leads to serious health risks for living organisms. Growth, development, metabolic system, and yield of crops are drastically diminished by exposure to As.
Zesmin Khan, Thorny Chanu Thounaojam, Hrishikesh Upadhyaya   +2 more
doaj   +1 more source

Structural insights into drug transport by an aquaglyceroporin. [PDF]

Nat Commun
AbstractPentamidine and melarsoprol are primary drugs used to treat the lethal human sleeping sickness caused by the parasite Trypanosoma brucei. Cross-resistance to these two drugs has recently been linked to aquaglyceroporin 2 of the trypanosome (TbAQP2).
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C.   +10 more
europepmc   +4 more sources

Mind the Porins: Differential Effects of Porin Knockouts and Overexpression on Glucose and Xylose Uptake and Utilization in Pseudomonas putida

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
Altering the levels of outer membrane (OM) porins has an effect on the dynamics of the utilization and co‐utilization of native (glucose—green hexagon) and non‐native (xylose—brown pentagon) sugars, as well as the accumulation of their oxidation byproducts in Pseudomonas putida cultures.
Barbora Popelářová, Nicolas T. Wirth, Daniel C. Volke, Tibor Botka, Pablo I. Nikel, Pavel Dvořák   +5 more
wiley   +1 more source