Results 11 to 20 of about 1,373 (155)
Crystallization of Human Aquaglyceroporins for Neutron Diffraction Studies [PDF]
ACS OmegaAquaglyceroporins are channels that facilitate the flux of glycerol and water across lipid bilayers. Although structural information is available for several aquaglyceroporins, the details of how water and glycerol selectivity are maintained and how protons are excluded remain elusive.
Sofia W. de Maré +8 more
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Aquaglyceroporins: Drug Targets for Metabolic Diseases? [PDF]
Frontiers in Physiology, 2018 Aquaporins (AQPs) are a family of transmembrane channel proteins facilitating the transport of water, small solutes, and gasses across biological membranes.
Giuseppe Calamita +2 more
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Aquaporins in sepsis- an update [PDF]
Frontiers in ImmunologyAquaporins (AQPs), a family of membrane proteins that facilitate the transport of water and small solutes, have garnered increasing attention for their role in sepsis, not only in fluid balance but also in immune modulation and metabolic regulation ...
Katharina Rump, Michael Adamzik
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Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases
Frontiers in Molecular Biosciences, 2022 Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol and other small uncharged solutes across cell membranes, have been recognized for their important role in human physiology and their involvement in multiple ...
Catarina Pimpão +7 more
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Cells, 2022 Background: Aquaporins are membrane channels responsible for the bidirectional transfer of water and small non-charged solutes across cell membranes. AQP3 and AQP5 are overexpressed in pancreatic ductal adenocarcinoma, playing key roles in cell migration,
Patrícia M. Silva +6 more
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Cells, 2021 Septic shock is the most severe complication of sepsis, being characterized by a systemic inflammatory response following bacterial infection, leading to multiple organ failure and dramatically high mortality.
Angela Tesse +3 more
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Functional characterization of a microbial aquaglyceroporin [PDF]
Microbiology, 2001 The major intrinsic proteins (MIPs) constitute a widespread membrane channel family essential for osmotic cell equilibrium. The MIPs can be classified into three functional subgroups: aquaporins, glycerol facilitators and aquaglyceroporins. Bacterial MIP genes have been identified in archaea as well as in Gram-positive and Gram-negative eubacteria ...
Alexandrine, Froger +9 more
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Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in db/db Mice
Cells, 2022 Aquaporin-9 (AQP9) is a facilitator of glycerol and other small neutral solute transmembrane diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult, due to high sequence similarity between the 13 human isoforms,
Marilina Florio +11 more
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The Mechanism of Glycerol Conduction in Aquaglyceroporins [PDF]
Structure, 2001 The E. coli glycerol facilitator, GlpF, selectively conducts glycerol and water, excluding ions and charged solutes. The detailed mechanism of the glycerol conduction and its relationship to the characteristic secondary structure of aquaporins and to the NPA motifs in the center of the channel are unknown.Molecular dynamics simulations of GlpF reveal ...
Jensen, Morten Ø. +2 more
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Arsenic transport by zebrafish aquaglyceroporins [PDF]
BMC Molecular Biology, 2009 Abstract Background Arsenic is one of the most ubiquitous toxins and endangers the health of tens of millions of humans worldwide. It is a mainly a water-borne contaminant. Inorganic trivalent arsenic (AsIII) is one of the major species that exists environmentally.
Hamdi, Mohamad +6 more
openaire +3 more sources