Aquaporin-9 facilitates liver regeneration following hepatectomy [PDF]
Redox Biology, 2022 Aquaporin-9 (AQP9) is an aquaglyceroporin strongly expressed in the basolateral membrane of hepatocytes facing the sinusoids. AQP9 is permeable to hydrogen peroxide (H2O2) and glycerol as well as to water.
Bo Zhang +9 more
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The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker [PDF]
Biomolecules, 2022 Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis ...
Inês V. da Silva +3 more
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Analysis of aquaporin 9 expression in human epidermis and cultured keratinocytes [PDF]
FEBS Open Bio, 2014 Aquaporin 9 (AQP9) is a member of the aquaglyceroporin family that transports glycerol, urea and other small solutes as well as water. Compared to the expression and function in epidermal keratinocytes of AQP3, another aquaglyceroporin, our knowledge of ...
Yoshinori Sugiyama +5 more
doaj +5 more sources
Changes in retinal aquaporin-9 (AQP9) expression in glaucoma [PDF]
Bioscience Reports, 2013 The eye contains numerous water channel proteins and the roles of AQPs (aquaporins) in the retina are blurred, especially under disease conditions. The purpose of this study was to investigate the expression of AQP9 gene and proteins affected by elevated
Ming‑Hui Yang +2 more
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The Host Protein Aquaporin-9 is Required for Efficient Plasmodium falciparum Sporozoite Entry into Human Hepatocytes [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Hepatocyte invasion by Plasmodium sporozoites represents a promising target for innovative antimalarial therapy, but the molecular events mediating this process are still largely uncharacterized. We previously showed that Plasmodium falciparum sporozoite
Nadia Amanzougaghene +23 more
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Lactic Acid Transport Mediated by Aquaporin-9: Implications on the Pathophysiology of Preeclampsia [PDF]
Frontiers in Physiology, 2021 Aquaporin-9 (AQP9) expression is significantly increased in preeclamptic placentas. Since feto-maternal water transfer is not altered in preeclampsia, the main role of AQP9 in human placenta is unclear.
Yollyseth Medina +7 more
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Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in db/db Mice [PDF]
Cells, 2022 Aquaporin-9 (AQP9) is a facilitator of glycerol and other small neutral solute transmembrane diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult, due to high sequence similarity between the 13 human isoforms,
Marilina Florio +11 more
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Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap [PDF]
Life, 2022 (1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was ...
Katharina Geistlinger +2 more
doaj +2 more sources
Prognostic implications of Aquaporin 9 expression in clear cell renal cell carcinoma [PDF]
Journal of Translational Medicine, 2019 Background Growing evidence has demonstrated immune reactivity as a confirmed important carcinogenesis and therapy efficacy for clear cell renal cell carcinoma (ccRCC).
Wen-Hao Xu +9 more
doaj +2 more sources
MicroRNA-181a/b-1 enhances chondroprogenitor anabolism and downregulates aquaporin-9 [PDF]
Osteoarthritis and Cartilage OpenObjective: Effective osteoarthritis treatments that enhance the anabolic/regenerative capacity of chondrocytes are needed. Studying cartilage development processes may inform us of approaches to control chondrocyte differentiation and anabolism and ...
Austin Bell-Hensley +6 more
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