Results 11 to 20 of about 33,882 (227)

RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis [PDF]

Frontiers in Immunology, 2022
Sepsis is caused by systemic infection and is a major health concern as it is the primary cause of death from infection. It is the leading cause of mortality worldwide and there are no specific effective treatments for sepsis.
Shireen Mohammad, Caroline E. O’Riordan, Chiara Verra, Eleonora Aimaretti, Gustavo Ferreira Alves, Klaus Dreisch, Johan Evenäs, Patrizia Gena, Angela Tesse, Michael Rützler, Michael Rützler, Massimo Collino, Giuseppe Calamita, Christoph Thiemermann   +13 more
doaj   +2 more sources

Changes in expression of aquaporin-4 and aquaporin-9 in optic nerve after crushing in rats. [PDF]

PLoS ONE, 2014
The purpose of this study was to determine the temporal and spatial changes in the expression of AQP4 and AQP9 in the optic nerve after it is crushed. The left optic nerves of rats were either crushed (crushed group) or sham operated (sham group), and ...
Hiroyuki Suzuki, Hidehiro Oku, Taeko Horie, Seita Morishita, Masahiro Tonari, Kazuma Oku, Akiko Okubo, Teruyo Kida, Masashi Mimura, Masanori Fukumoto, Shota Kojima, Shinji Takai, Tsunehiko Ikeda   +12 more
doaj   +2 more sources

Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9 [PDF]

Cells, 2018
High 17β-Estradiol (E2) levels are known to cause alterations of spermatogenesis and environments throughout the male reproductive tract. Sertoli cells (SCs) ensure an adequate environment inside the seminiferous tubule. Glycerol stands as essential
Raquel L. Bernardino, David F. Carrageta, Ana M. Silva, Giuseppe Calamita, Marco G. Alves, Graça Soveral, Pedro F. Oliveira   +6 more
doaj   +2 more sources

Ablation of Aquaporin-9 Ameliorates the Systemic Inflammatory Response of LPS-Induced Endotoxic Shock in Mouse [PDF]

Cells, 2021
Septic shock is the most severe complication of sepsis, being characterized by a systemic inflammatory response following bacterial infection, leading to multiple organ failure and dramatically high mortality.
Angela Tesse, Patrizia Gena, Michael Rützler, Giuseppe Calamita   +3 more
doaj   +2 more sources

Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity. [PDF]

Sci Rep, 2015
AbstractAquaporin-9 (AQP9), a water/glycerol channel protein, is expressed in several immune cells including neutrophils; however, its role in immune response remains unknown. Here we show the involvement of AQP9 in hapten-induced contact hypersensitivity (CHS), as a murine model of skin allergic contact dermatitis, using AQP9 knockout (AQP9−/−) mice ...
Moniaga CS, Watanabe S, Honda T, Nielsen S, Hara-Chikuma M.   +4 more
europepmc   +5 more sources

Aquaporin-9 Contributes to the Maturation Process and Inflammatory Cytokine Secretion of Murine Dendritic Cells [PDF]

Frontiers in Immunology, 2018
Dendritic cells (DCs) are the most potent antigen-presenting cells able to trigger the adaptive immune response to specific antigens. When non-self-antigens are captured, DCs switch from an “immature” to a “mature” state to fulfill their function.
Stefania De Santis, Stefania De Santis, Stefania De Santis, Grazia Serino, Maria R. Fiorentino, Vanessa Galleggiante, Patrizia Gena, Giulio Verna, Marina Liso, Monica Massaro, Jinggang Lan, Jacopo Troisi, Jacopo Troisi, Ilaria Cataldo, Alessia Bertamino, Aldo Pinto, Pietro Campiglia, Pietro Campiglia, Angelo Santino, Gianluigi Giannelli, Alessio Fasano, Alessio Fasano, Giuseppe Calamita, Marcello Chieppa, Marcello Chieppa   +24 more
doaj   +2 more sources

Aquaporin 9 downregulation in KRASG12V colorectal cancer and associated with increased proliferation and decreased apoptosis in cancer cells [PDF]

Scientific Reports
Patients with colorectal cancer (CRC) carrying KRAS mutations face a challenging prognosis, especially due to their reduced response to EGFR inhibitor therapies.
Yankui Liu, Jiahao Dou, Qi Tan, Shuning Chen, Yaru Li, Rong Wang, Ning Sun, Xiaowei Qi   +7 more
doaj   +2 more sources

Aquaporin-9 as a biomarker for hydrocephalus: Insights from experimental rat models. [PDF]

Surg Neurol Int
Background Hydrocephalus, characterized by ventricular enlargement often associated with elevated intracranial pressure, necessitates reliable biomarkers for accurate diagnosis. Aquaporin-9 (AQP-9), localized at the interface of cerebrospinal fluid (CSF) spaces and blood vessels, plays a critical role in brain water homeostasis but remains ...
Kusumo C, Parenrengi MA, Suryaningtyas W, Fahmi A, Utomo B, Sudiana IK.   +5 more
europepmc   +3 more sources

A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues. [PDF]

J Histochem Cytochem, 2016
AQP9 is known to facilitate hepatocyte glycerol uptake. Murine AQP9 protein expression has been verified in liver, skin, epididymis, epidermis and neuronal cells using knockout mice. Further expression sites have been reported in humans. We aimed to verify AQP9 expression in a large set of human normal organs, different cancer types, rheumatoid ...
Lindskog C, Asplund A, Catrina A, Nielsen S, Rützler M.   +4 more
europepmc   +7 more sources

Intravoxel incoherent motion MRI for early detection and assessment of renal injury after cardiac arrest and resuscitation in a rat model [PDF]

European Radiology Experimental
Objective To investigate the utility of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) for early detection of renal injury 24 h after cardiac arrest and cardiopulmonary resuscitation.
Jie Zhang, Na Zhan, Haoyi Ye, Siqi Liu, Yunke Tan, Jinzhao Zhang, Teng Huang, Zhihua Wu, Zhengfei Yang, Zhifeng Liu   +9 more
doaj   +2 more sources