Results 61 to 70 of about 4,789 (161)

Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9

Cells, 2018
High 17β-Estradiol (E2) levels are known to cause alterations of spermatogenesis and environments throughout the male reproductive tract. Sertoli cells (SCs) ensure an adequate environment inside the seminiferous tubule. Glycerol stands as essential
Raquel L. Bernardino, David F. Carrageta, Ana M. Silva, Giuseppe Calamita, Marco G. Alves, Graça Soveral, Pedro F. Oliveira   +6 more
doaj   +1 more source

Parallel Genomic Remodelling Associated With Independent Terrestrialization Events in Arthropods

Molecular Ecology, Volume 35, Issue 1, January 2026.
ABSTRACT The repeated transition from aquatic to terrestrial environments (terrestrialization) has shaped the evolutionary trajectory of many animal lineages, yet the genomic basis of this ecological shift remains incompletely understood. Arthropods, with multiple independent terrestrialization events, provide a powerful system to investigate whether ...
Lisandra Benítez‐Álvarez, Vanina Tonzo, Leandro Aristide, Rosa Fernández   +3 more
wiley   +1 more source

AQP9 promotes astrocytoma cell invasion and motility via the AKT pathway

Oncology Letters, 2018
The aquaporin (AQP) family, which includes 13 members identified in mammalian cells, is involved in cancer development and progression. AQP9 expression is upregulated in several tumor tissue types. However, the functions of AQP9 in astrocytoma remain elusive. The present study identified that AQP9 was expressed in astrocytoma cells. AQP9 expression was
Yao, Lv, Qiang, Huang, Weimin, Dai, Yuanqing, Jie, Guofeng, Yu, Xiaofeng, Fan, An, Wu, Qian, Miao   +7 more
openaire   +3 more sources

Mining Chemotherapy Resistance Related Genes in Breast Cancer to Construct a New Prognosis Prediction Model‐Based on GEO Database and Real‐World Study

Human Mutation, Volume 2026, Issue 1, 2026.
Objective The chemotherapy resistance genes in breast cancer are closely related to prognosis. This study is aimed at exploring the key genes that may be involved in chemotherapy resistance of breast cancer and establishing a prognostic model. Methods Using data from the GEO database, differentially expressed genes (DEGs) related to chemotherapy ...
Zhaozhen Qiu, Xiaodong Dai, Jianfeng Zeng, Lin Zhang   +3 more
wiley   +1 more source

A Clinically Applicable Diagnostic Framework for Acute Myocardial Infarction: Leveraging Multiomics and Machine Learning to Decipher LPS‐Associated Immune Signatures

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Background The early and accurate diagnosis of acute myocardial infarction (AMI) remains a critical challenge in clinical practice. While inflammation is a cornerstone of AMI pathogenesis, translating specific inflammatory pathways into clinically actionable tools requires an integrative analytical approach.
Bo He, Yongsheng Qu, Zhixing Guo, Yahui Liu, Zheng Zhang, Chuanyu Gao, Zhiwen Luo   +6 more
wiley   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

Pseudomonas aeruginosa N-3-oxo-dodecanoyl-homoserine lactone elicits changes in cell volume, morphology and AQP9 characteristics in macrophages

Frontiers in Cellular and Infection Microbiology, 2016
Quorum sensing (QS) communication allows P. aeruginosa to collectively control its population density and the production of biofilms and virulence factors.
Angelika eHolm, Karl-Eric eMagnusson, Elena eVikström   +2 more
doaj   +1 more source

Transmembrane Facilitation of Lactate/H⁺ Instead of Lactic Acid Is Not a Question of Semantics but of Cell Viability

Membranes, 2020
Transmembrane transport of monocarboxylates is conferred by structurally diverse membrane proteins. Here, we describe the pH dependence of lactic acid/lactate facilitation of an aquaporin (AQP9), a monocarboxylate transporter (MCT1, SLC16A1), and a ...
Annika Bader, Eric Beitz
doaj   +1 more source

Phenotypic Changes in a Monocyte Cluster with High Interleukin‐1 Beta Expression during Long‐Term Anti‐CD20 Therapy

Annals of Neurology, Volume 98, Issue 6, Page 1283-1298, December 2025.
[Color figure can be viewed at www.annalsofneurology.org] Graphical abstract illustrating the study design, experimental workflow, and key findings from single‐cell profiling of peripheral mononuclear cells in multiple sclerosis patients undergoing anti‐CD20 therapy, revealing disease‐ and treatment‐associated immune signatures.
Mie Waede, Christina Kingo, Karina Damsbo, Maiken Uhrbrand Joergensen, Mhaned Oubounyt, Morten Gjerstorff, Mads Thomassen, Jan Baumbach, Jesper B. Moeller, Maria L. Elkjaer, Zsolt Illes   +10 more
wiley   +1 more source

AQP3 and AQP9 [PDF]

Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and organ-organ interaction networks. Potential drug targets can depict aquaporins, as they are involved in immunological processes. In immune cells, AQP3 and AQP9 are of special interest.
Thon, Patrick (M. Sc.), Rahmel, Tim (PD Dr. med.), Ziehe, Dominik (Dr. rer. nat.), Palmowski, Lars (Dr. med.), Marko, Britta (Dr. med.), Nowak, Hartmuth Sebastian Burkhard (PD Dr. med.), Wolf, Alexander (Dr. med.), Witowski, Andrea Annette (Dr. med.), Orlowski, Jennifer, Ellger, Björn (Prof. Dr. med.), Wappler, Frank (Prof. Dr. med.), Schwier, Elke Ute (Dr. rer.nat.), Henzler, Dietrich (Prof. Dr. med.), Köhler, Thomas (Dr. med.), Zarbock, Alexander (Univ.-Prof. Dr. med.), Ehrentraut, Stefan Felix (PD Dr. med.), Putensen, Christian (Prof. Dr. med.), Frey, Ulrich (Prof. Dr. med.), Anft, Moritz (Dr. rer. nat.), Babel, Nina (Prof. Dr. med.), Sitek, Barbara (Prof. Dr.), Adamzik, Michael (Prof. Dr. med.), Bergmann, Lars (Priv.-Doz. Dr. med.), Unterberg, Matthias (Dr. med.), Koos, Björn (PD Dr. rer. nat.), Rump, Katharina (Dr. rer. nat.)   +25 more
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