Results 61 to 70 of about 1,989 (206)

Orchid genome evolution and trait innovation

Journal of Integrative Plant Biology, EarlyView.
Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng, Cheng‐Yuan Zhou, Linying Wang, Jie Gao, Weilun Yin, Dong‐Hui Peng, Siren Lan, Feng‐Xi Yang, Zhong‐Jian Liu   +8 more
wiley   +1 more source

Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs [PDF]

International Journal of Molecular Sciences, 2018
Nuclear receptors, such as the farnesoid X receptor (FXR) and the peroxisome proliferator-activated receptors gamma and alpha (PPAR-γ, -α), are major metabolic regulators in adipose tissue and the liver, where they govern lipid, glucose, and bile acid homeostasis, as well as inflammatory cascades.
Matteo Tardelli, Thierry Claudel, Francesca Virginia Bruschi, Michael Trauner   +3 more
openaire   +2 more sources

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

Analysis of aquaporin 9 expression in human epidermis and cultured keratinocytes

FEBS Open Bio, 2014
Aquaporin 9 (AQP9) is a member of the aquaglyceroporin family that transports glycerol, urea and other small solutes as well as water. Compared to the expression and function in epidermal keratinocytes of AQP3, another aquaglyceroporin, our knowledge of ...
Yoshinori Sugiyama, Kohei Yamazaki, Ayumi Kusaka-Kikushima, Kyoko Nakahigashi, Hiromi Hagiwara, Yoshiki Miyachi   +5 more
doaj   +1 more source

Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound. [PDF]

PLoS ONE, 2012
Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as glycerol and are involved in many physiological functions. Aquaporin-based modulator drugs are predicted to be of broad potential utility in the treatment of several ...
Ana Paula Martins, Alessandro Marrone, Antonella Ciancetta, Ana Galán Cobo, Miriam Echevarría, Teresa F Moura, Nazzareno Re, Angela Casini, Graça Soveral   +8 more
doaj   +1 more source

The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker

Biomolecules, 2022
Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis ...
Inês V. da Silva, Sabino Garra, Giuseppe Calamita, Graça Soveral   +3 more
doaj   +1 more source

Mind the Porins: Differential Effects of Porin Knockouts and Overexpression on Glucose and Xylose Uptake and Utilization in Pseudomonas putida

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
Altering the levels of outer membrane (OM) porins has an effect on the dynamics of the utilization and co‐utilization of native (glucose—green hexagon) and non‐native (xylose—brown pentagon) sugars, as well as the accumulation of their oxidation byproducts in Pseudomonas putida cultures.
Barbora Popelářová, Nicolas T. Wirth, Daniel C. Volke, Tibor Botka, Pablo I. Nikel, Pavel Dvořák   +5 more
wiley   +1 more source

Dynamics and energetics of solute permeation through the Plasmodium falciparum aquaglyceroporin [PDF]

, 2010
The aquaglyceroporin from Plasmodium falciparum (PfAQP) is a potential drug target for the treatment of malaria. It efficiently conducts water and other small solutes, and is proposed to intervene in several crucial physiological processes during the ...
Bert L. de Groot, Hub, Jochen S., Camilo Aponte-Santamaría, Hub, Jochen S.,, Aponte-Santamaría, Camilo, Jochen S. Hub, de Groot, Bert L.   +6 more
core   +1 more source

Gold(III) Pyridine-Benzimidazole Complexes as Aquaglyceroporin Inhibitors and Antiproliferative Agents

Inorganics, 2018
Gold compounds have been proven to be novel and versatile tools for biological applications, including as anticancer agents. Recently, we explored the potential of Au(III) complexes with bi-dentate N-donor ligands as inhibitors of the membrane water and ...
Brech Aikman, Margot N. Wenzel, Andreia F. Mósca, Andreia de Almeida, Wim T. Klooster, Simon J. Coles, Graça Soveral, Angela Casini   +7 more
doaj   +1 more source

An Atypical Aquaporin 1 Derived From Paramecium multimicronucleatum Functions as a Multifunctional Channel That Permeates Water, Glycerol, and Urea

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Although it had been reported that the translation product of the functional aquaporin gene, aqp1, is localized to the contractile vacuole complex of Paramecium multimicronucleatum, the molecules that pass through this channel protein had not been identified. In the present study, we introduced and expressed this protein in Xenopus oocytes and
Masaki Ishida, Shuichi Ueno, Takashi Tominaga, Kurumi Tanaka, Akito Horikawa, Manabu Hori   +5 more
wiley   +1 more source