Results 1 to 10 of about 13,009 (197)

Exploring monocarboxylate transporter inhibition for cancer treatment [PDF]

Exploration of Targeted Anti-tumor Therapy
Cells are separated from the environment by a lipid bilayer membrane that is relatively impermeable to solutes. The transport of ions and small molecules across this membrane is an essential process in cell biology and metabolism.
Tomas Koltai, Larry Fliegel
doaj   +4 more sources

A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. [PDF]

PLoS Genetics, 2023
Brains are highly metabolically active organs, consuming 20% of a person's energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases.
Dongwei Xu, Alec Vincent, Andrés González-Gutiérrez, Benjamin Aleyakpo, Sharifah Anoar, Ashling Giblin, Magda L Atilano, Mirjam Adams, Dunxin Shen, Annora Thoeng, Elli Tsintzas, Marie Maeland, Adrian M Isaacs, Jimena Sierralta, Teresa Niccoli   +14 more
doaj   +4 more sources

Genome-Wide Analysis Reveals Expansion and Positive Selection of Monocarboxylate Transporter Genes Linked to Enhanced Salinity and Ammonia Tolerance in Sinonovacula constricta [PDF]

Animals
Our previous genome analysis of Sinonovacula constricta revealed an expansion of the monocarboxylate transporter gene family, which is crucial for metabolic dynamic balance and intracellular pH regulation.
Yiping Meng, Liyuan Lv, Hanhan Yao, Zhihua Lin, Yinghui Dong   +4 more
doaj   +2 more sources

Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression [PDF]

Biomarker Research
Background Tumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding metabolic diversity in retinoblastoma (RB), the primary intraocular malignancy in children, remains limited.
Junjie Tang, Yaoming Liu, Yinghao Wang, Zhihui Zhang, Jiahe Nie, Xinyue Wang, Siming Ai, Jinmiao Li, Yang Gao, Cheng Li, Chao Cheng, Shicai Su, Shuxia Chen, Ping Zhang, Rong Lu   +14 more
doaj   +2 more sources

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor Microenvironment [PDF]

Cancer Management and Research, 2023
Shangcong Han, Guiming Zhang, Tian Liu   +2 more
exaly   +2 more sources

Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review [PDF]

International Journal of Molecular Sciences, 2023
Filipa Pinto-Ribeiro, Baltazar F, Marta Costa   +2 more
exaly   +2 more sources

Hypoxia-inducible factor 1a (HIF 1a) and monocarboxylate transporter 1 (MCT 1) in papillary thyroid carcinoma; A study in Sulaimani City/Iraq

Advanced Medical Journal, 2023
Background and objectives: Papillary thyroid carcinoma is one of the most common cancers of human, monocarbox- ylate transporter 1 and hypoxia inducible factor 1 alpha expressions in many tumors have recently being targets for treatment, HIF-1a has been
Hadeel Adnan Yasseen, Ari Mohammed Abdullah   +1 more
doaj   +1 more source

MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

Communications Biology, 2022
Analogs of methyl-oxalylglycine (MOG) were generated as tools to study the monocarboxylate transporter MCT2, an understudied SLC16 family member. These compounds still inhibit prolyl hydroxylases but have minimal metabolic and cytotoxic effects.
Louise Fets, Natalie Bevan, Patrícia M. Nunes, Sebastien Campos, Mariana Silva dos Santos, Emma Sherriff, James I. MacRae, David House, Dimitrios Anastasiou   +8 more
doaj   +1 more source

MCT2 overexpression promotes recovery of cognitive function by increasing mitochondrial biogenesis in a rat model of stroke

Animal Cells and Systems, 2021
Monocarboxylate transporter 2 (MCT2) is the predominant monocarboxylate transporter expressed by neurons. MCT2 plays an important role in brain energy metabolism. Stroke survivors are at high risk of cognitive impairment.
Xiaorong Yu, Rui Zhang, Cunsheng Wei, Yuanyuan Gao, Yanhua Yu, Lin Wang, Junying Jiang, Xuemei Zhang, Junrong Li, Xuemei Chen   +9 more
doaj   +1 more source

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

Haematologica, 2017
Inhibition of monocarboxylate transporter 1 has been proposed as a therapeutic approach to perturb lactate shuttling in tumor cells that lack monocarboxylate transporter 4.
Richard A. Noble, Natalie Bell, Helen Blair, Arti Sikka, Huw Thomas, Nicole Phillips, Sirintra Nakjang, Satomi Miwa, Rachel Crossland, Vikki Rand, Despina Televantou, Anna Long, Hector C. Keun, Chris M. Bacon, Simon Bomken, Susan E. Critchlow, Stephen R. Wedge   +16 more
doaj   +1 more source