Results 1 to 10 of about 161 (83)

Ablation of Glucokinase-Expressing Tanycytes Impacts Energy Balance and Increases Adiposity in Mice

Molecular Metabolism, 2021
Objectives: Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in mice
Irina Kolotuev, Emilie Caron, Federico A Santoni   +2 more
exaly   +3 more sources

NF-κB Signaling in Tanycytes Mediates Inflammation-Induced Anorexia

Molecular Metabolism, 2020
Objectives: Infections, cancer, and systemic inflammation elicit anorexia. Despite the medical significance of this phenomenon, the question of how peripheral inflammatory mediators affect the central regulation of food intake is incompletely understood.
Jan Wenzel, David Engblom, Vincent Prevot   +2 more
exaly   +3 more sources

Hypothalamic Tanycytes—Masters and Servants of Metabolic, Neuroendocrine, and Neurogenic Functions

Frontiers in Neuroscience, 2015
There is a resurgent interest in tanycytes, a radial glial-like cell population occupying the floor and ventro-lateral walls of the third ventricle (3V).
Mohammad K Hajihosseini
exaly   +3 more sources

Amino Acid Sensing in Hypothalamic Tanycytes via Umami Taste Receptors

Molecular Metabolism, 2017
Objective: Hypothalamic tanycytes are glial cells that line the wall of the third ventricle and contact the cerebrospinal fluid (CSF). While they are known to detect glucose in the CSF we now show that tanycytes also detect amino acids, important ...
Alice Solda', Greta Lazutkaite, Nicholas Dale   +2 more
exaly   +3 more sources

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances
The hypothalamus coordinates energy‐balance regulation and is also a neurogenic/plastic region in the adult brain. Tanycytes, a specialized population of radial glial‐like cells lining the third ventricle, reside at the critical interface between the ...
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
doaj   +2 more sources

Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes

Frontiers in Neuroscience, 2022
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche.
Alex Moore, Alex Moore, Alex Moore, Kavitha Chinnaiya, Kavitha Chinnaiya, Kavitha Chinnaiya, Dong Won Kim, Sarah Brown, Sarah Brown, Sarah Brown, Iain Stewart, Iain Stewart, Iain Stewart, Sarah Robins, Sarah Robins, Sarah Robins, Georgina K. C. Dowsett, Georgina K. C. Dowsett, Charlotte Muir, Marco Travaglio, Jo E. Lewis, Jo E. Lewis, Fran Ebling, Seth Blackshaw, Seth Blackshaw, Seth Blackshaw, Seth Blackshaw, Seth Blackshaw, Andrew Furley, Andrew Furley, Andrew Furley, Marysia Placzek, Marysia Placzek, Marysia Placzek   +33 more
doaj   +1 more source

A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System

iScience, 2020
Summary: Based on the type-I cannabinoid receptor (CB1) content of hypophysiotropic axons and the involvement of tanycytes in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis, we hypothesized that endocannabinoids are involved in the ...
Erzsébet Farkas, Edina Varga, Balázs Kovács, Anett Szilvásy-Szabó, Antonieta Cote-Vélez, Zoltán Péterfi, Magdalini Matziari, Mónika Tóth, Dóra Zelena, Zsolt Mezriczky, Andrea Kádár, Dóra Kővári, Masahiko Watanabe, Masanobu Kano, Ken Mackie, Balázs Rózsa, Yvette Ruska, Blanka Tóth, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Balázs Gereben, Ronald M. Lechan, Jean-Louis Charli, Patricia Joseph-Bravo, Csaba Fekete   +25 more
doaj   +1 more source

Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice

Nature Communications, 2021
Tanycytes contribute to the regulation of multiple hypothalamic functions. Here the authors investigate the regenerative and tumorigenic potential of adult Rax+ tanycytes in the median eminence in the context of the stem cell niche in mice.
Wenhui Mu, Si Li, Jingkai Xu, Xize Guo, Haoda Wu, Zhenhua Chen, Lianyong Qiao, Gisela Helfer, Falong Lu, Chong Liu, Qing-Feng Wu   +10 more
doaj   +1 more source

Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males

Frontiers in Endocrinology, 2022
In adult mammals, neural stem cells are localized in three neurogenic regions, the subventricular zone of the lateral ventricle (SVZ), the subgranular zone of the dentate gyrus of the hippocampus (SGZ) and the hypothalamus. In the SVZ and the SGZ, neural
Lucile Butruille, Martine Batailler, Marie-Line Cateau, Ariane Sharif, Valérie Leysen, Vincent Prévot, Pascal Vaudin, Delphine Pillon, Martine Migaud   +8 more
doaj   +1 more source

MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction.

PLoS ONE, 2011
Metabolic interaction via lactate between glial cells and neurons has been proposed as one of the mechanisms involved in hypothalamic glucosensing. We have postulated that hypothalamic glial cells, also known as tanycytes, produce lactate by glycolytic ...
Christian Cortés-Campos, Roberto Elizondo, Paula Llanos, Romina María Uranga, Francisco Nualart, María Angeles García   +5 more
doaj   +1 more source