Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice
Molecular Metabolism, 2021 Objectives: Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in mice
Emilie Caron +2 more
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Compartmentalized VEGF receptor expression in hypothalamic tanycytes reveals a novel non-endothelial axis of VEGF signaling [PDF]
Fluids and Barriers of the CNSBackground Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are critical regulators of angiogenesis and vascular homeostasis. While VEGF signaling has been extensively studied in endothelial cells, emerging evidence suggests it ...
Ombeline Desruelle +7 more
doaj +2 more sources
Tanycytic G6PT silencing prevents obesity induced by early postnatal overnutrition [PDF]
Scientific ReportsTanycytes are ependymal glial cells that express the glucose-6-phosphate transporter (G6PT), which facilitates the incorporation of phosphorylated glucose from the cytosol into the reticular lumen.
María José Barahona +5 more
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Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale [PDF]
FASEB BioAdvancesThe hypothalamus coordinates energy‐balance regulation and is also a neurogenic/plastic region in the adult brain. Tanycytes, a specialized population of radial glial‐like cells lining the third ventricle, reside at the critical interface between the ...
Tianyi Tao +3 more
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NF-κB signaling in tanycytes mediates inflammation-induced anorexia
Molecular Metabolism, 2020 Objectives: Infections, cancer, and systemic inflammation elicit anorexia. Despite the medical significance of this phenomenon, the question of how peripheral inflammatory mediators affect the central regulation of food intake is incompletely understood.
Helge Müller-Fielitz +2 more
exaly +3 more sources
Hypothalamic tanycytes—masters and servants of metabolic, neuroendocrine, and neurogenic functions
Frontiers in Neuroscience, 2015 There is a resurgent interest in tanycytes, a radial glial-like cell population occupying the floor and ventro-lateral walls of the third ventricle (3V).
Mohammad K Hajihosseini +1 more
exaly +3 more sources
Amino acid sensing in hypothalamic tanycytes via umami taste receptors
Molecular Metabolism, 2017 Objective: Hypothalamic tanycytes are glial cells that line the wall of the third ventricle and contact the cerebrospinal fluid (CSF). While they are known to detect glucose in the CSF we now show that tanycytes also detect amino acids, important ...
Greta Lazutkaite +2 more
exaly +3 more sources
Adenosine transmission from hypothalamic tanycytes to AGRP/NPY neurons regulates energy homeostasis [PDF]
Experimental and Molecular MedicineTanycytes are a pivotal component of the hypothalamic network that controls energy homeostasis. Despite their importance, the regulatory mechanisms governing tanycyte–neuron interactions in response to metabolic signals remain unexplored.
Nayoun Kim +3 more
doaj +2 more sources
A single-cell transcriptomic study of heterogeneity in human embryonic tanycytes [PDF]
Scientific ReportsDisruptions in energy homeostasis can lead to diseases like obesity and diabetes, affecting millions of people each year. Tanycytes, the adult stem cells in the hypothalamus, play crucial roles in assisting hypothalamic neurons in maintaining energy ...
Yiguang Bai, Qiaoling Chen, Yuan Li
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Potential role of tanycyte-derived neurogenesis in Alzheimer’s disease [PDF]
Neural Regeneration ResearchTanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance.
Guibo Qi +4 more
doaj +2 more sources